Browsing by Author "Fan, S. -K."

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Dielectric droplet manipulations by electropolarization forces
(2008)
Hsieh, T. -H.
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Fan, S. -K.
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材料科學與工程學系奈米科技碩博班
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Graduate Program of Nanotechnology , Department of Materials Science and Engineering
Dielectric droplets are successfully manipulated by electropolarization forces in a parallel plate device, which extends the liquid handling capability of digital microfluidics from merely conductive droplets to dielectric ones. Actuations of silicone oil, decane, and hexadecane droplets in a 150-mu m-high gap between parallel plates are demonstrated. Silicone oil droplets of different viscosities, 20 and 50 cSt, are transported and split in various gaps heights, demonstrating the manipulation capabilities of electropolarization forces. The threshold and splitting voltages are measured and compared. Moreover, the relationship between the velocity and driving voltage is studied.
Digital microfluidic operations on micro-electrode dot array architecture
(2011-12-01)
Wang, G.
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Teng, D.
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Fan, S. -K.
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材料科學與工程學系
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Department of Materials Science and Engineering
As digital microfluidics-based biochips find more applications, their complexity is expected to increase significantly owing to the trend of multiple and concurrent assays on the chip. There is a pressing need to deliver a top-down design methodology that the biochip designer can leverage the same level of computer-aided design support as the semi-conductor industry now does. Moreover, as microelectronics fabrication technology is scaling up and integrated device performance is improving, it is expected that these microfluidic biochips will be integrated with microelectronic components in next-generation system-on-chip designs. This study presents the analysis and experiments of digital microfluidic operations on a novel electrowetting-on-dielectric-based 'micro-electrode dot array architecture' that fosters a development path for hierarchical top-down design approach for digital microfluidics. The proposed architecture allows dynamic configurations and activations of identical basic microfluidic unit called 'micro-electrode cells' to design microfluidic components, layouts, routing, microfluidic operations and applications of the biochip hierarchically. Fundamental microfluidic operations have been successfully performed by the architecture. In addition, this novel architecture demonstrates a number of advantages and flexibilities over the conventional digital microfluidics in performing advanced microfluidic operations.
PROGRAMMABLE PROTEIN CRYSTALLIZATION IN METERED ENCAPSULATED DROPLETS
(2012)
Hsu, Y. -W.
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Chen, C. -H.
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Fan, S. -K.
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材料科學與工程學系
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Department of Materials Science and Engineering
We report for the first time programmable protein crystallization based on tunable evaporation and dissolution of salt and protein precipitants of an aqueous core droplet encapsulated in an oil shell. The evaporation depended on the precisely metered aqueous and oil droplet volumes and the position of the aqueous core droplet. The dissolution of the precipitants was achieved by adjusting the temperature of the aqueous core droplet. Lysozyme protein crystal was obtained within 80 min through (1) rapid salt/protein precipitation by fast evaporation, (2) salt dissolution by heating to enhance protein crystallization, and (3) protein crystallization from the protein precipitants (seeds) by slow evaporation.
Wristband-like droplet platform by digital microfluidic modularizations
(2008)
Yang, H.
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Hsu, W.
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Fan, S. -K.
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機械工程學系
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Department of Mechanical Engineering
Here a wristband-like platform is successfully demonstrated by the modularization technique of digital microfluidics. With proposed "plug-and-play" interfaces, various digital microfluidic modules can be easily assembled and disassembled, which is beneficial for module replacements and complex system integrations. Droplets are manipulated by clectrowetting in a wristband-like platform consisting two flexible modules, a basic connecting module, and an I/O connecting module. Droplets can be smoothly driven on the platform by electrowetting at the speed up to 105.7 mm/s when the supplying voltage is 120 V(AC) and the switching frequency is 70 Hz.