Browsing by Author "Fann, MJ"

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Efg1 involved in drug resistance by regulating the expression of ERG3 in Candida albicans
(2005-03-01)
Lo, HJ
;
Wang, JS
;
Lin, CY
;
Chen, CG
;
Hsiao, TY
The ERG3 gene in Candida albicans was identified as a gene whose mRNA level was higher in the cph1/cph1 efg1/efg1 double mutant than in the wild-type cells. Further study showed that Efg1, but not Cph1, negatively regulated ERG3. Mutations in EFG1 consistently increased the susceptibility of the cells to antifungal agents.