Browsing by Author "Gao, Xiaohu"

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Multifunctional Nanocapsules for Simultaneous Encapsulation of Hydrophilic and Hydrophobic Compounds and On-Demand Release
(2012-03-01)
Hu, Shang-Hsiu
;
Chen, San-Yuan
;
Gao, Xiaohu
;
材料科學與工程學系
;
Department of Materials Science and Engineering
Cocktail therapy by delivering multiple drugs to diseased cells can elicit synergistic therapeutic effects and better modulate the complex cell-signaling network. Besides selection of drug combinations, a difficulty in delivery is how to encapsulate drugs with various solubility into a common vehicle, particularly when both hydrophobic and hydrophilic compounds are involved. Furthermore, it is highly desirable that the drug release profile can be controlled in an on-demand fashion for balanced therapeutic and side effects. On the basis of a simple and scalable double emulsion approach, we report a new class of nanocapsules that can solve these problems simultaneously. Further linking the nanocapsules with peptides targeting cell surface integrins leads to significantly enhanced cell uptake of the nanocapsules. Intracellular drug release triggered by external stimuli has also been achieved without affecting cell viability. Further development of this technology should open exciting opportunities in treating tough diseases such as cancer, cardiovascular diseases, neurological disorders, and infectious diseases.
Nanocomposites with Spatially Separated Functionalities for Combined Imaging and Magnetolytic Therapy
(2010-06-02)
Hu, Shang-Hsiu
;
Gao, Xiaohu
;
材料科學與工程學系
;
Department of Materials Science and Engineering
Compact nanostructures with highly integrated functionalities are of considerable current interest to drug delivery, multimodality imaging, and electronic devices. A key challenge, however, is how to combine individual components together without interfering or sacrificing their original electronic and optical properties. Here, we demonstrate a new class of nanocomposites with spatially separated functionalities. We further demonstrate magnetic field modulated imaging and an innovative application of this technology in cancer cell treatment, magnetolytic therapy, based on magnetically controlled mechanical damage to cell membranes.