Browsing by Author "Ghukasyan, V."

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Hypericin-mediated selective photomodification of connective tissues
(2017-01-01)
Hovhannisyan, V.
;
Hovhannisyan, A.
;
Ghukasyan, V.
;
Guo, H. W.
;
Chen, Y. F.
Hypericin (Hyp) has received attention due to its high phototoxicity against viruses and anti-tumor photoactivity. Using two-photon imaging, we demonstrated that Hyp induced photosensitized modification of collagen fibers in native tissues. Dynamics of photo-processes was monitored by time-lapse multiphoton imaging. We showed that Hyp-mediated processes in collagen tissues may be used for the selective modification of collagen fibers.