Browsing by Author "Grumezescu, Alexandru Mihai"

Now showing 1 - 3 of 3

Alignment of Stretchable Nanoparticle Chains with Tunable Optical Properties Formed from Molecular Machinery
(2013-01-01)
Lin, Ming-Yu
;
Lu, Yen-Pei
;
Yang, Yuh-Shyong
;
Chen, Hsuen-Li
;
Yang, Chih-Hui
Control orientation and interparticle spacing of self-assembled nanoparticles can provide versatile functional materials for optical and electronic applications. In this study, we have obtained a glass substratum with tunable optical properties using flowing control and bimolecular competition. The surface of glass was modified from immobilized stretchable gold nanoparticle chains. The long and periodic single-stranded DNA nanotemplates were prepared using Phi29 DNA polymerase molecular machinery according to precise molecular biology regulation. Gold nanoparticle (Au NP) docked at the default sites of the nanotemplates and optical anisotropic absorption were enhanced by approximately 55 % by using tunable, flexible, and oriented one-dimensional metallic nanostructures.
Synthesis of uniform core-shell gelatin-alginate microparticles as intestine-released oral delivery drug carrier
(2014-02-01)
Huang, Keng-Shiang
;
Yang, Chih-Hui
;
Kung, Chao-Ping
;
Grumezescu, Alexandru Mihai
;
Ker, Ming-Dou
A core-shell gelatin-alginate composite used for intestine-released oral delivery drug carrier was synthesized through microfluidic technique. At the fixed continuous phase flow rate, the size of the core-shell gelatin-alginate microparticles increases with the dispersed phase flow rate, and monodispersity can be retained (the variation coefficient for the diameter distribution can be kept less than 10%). The fabricated microparticles could remain intact in gastric juice for at least 3 h, indicating that the gelatin core could be well protected by alginate shell in acid environment. However, the alginate shell of the microparticles would swell or collapse in alkali environment in half an hour, assuring the controlled drug release in intestinal juice. The fabricated uniform core-shell gelatin-alginate microparticles were potential as pH-responsive drug carriers.
Tumor Marker Detection by Aptamer-Functionalized Graphene Oxide
(2013-01-01)
Lin, Ming-Yu
;
Lu, Yen-Pei
;
Grumezescu, Alexandru Mihai
;
Ho, Fu Han
;
Kao, Ying-Hsien
Interaction of the single-stranded DNA (ssDNA) aptamers and proteins was investigated on graphene oxide (GO)-based biosensors. GO was applied for biological applications because of its unique properties, which include water dispensability, exclusive selection of ssDNA, and fluorescence-quenching effects. In this study, aptamer-functionalized GO sheets of nanometer-scale thickness and micrometer-scale dimension were developed. Based on a simple mixed-and-measured strategy, platelet-derived growth factors (PDGF), the tumor marker of ovarian cancer, triggered aptamers conformation switched and deliberated aptamers from GO surface according to thermal dynamic analysis. By functionalizing with various aptamers on GO, the strategy could provide designed functions on GO-based biosensors, bioreactors, and other devices.