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Browsing by Author "Guo, Ting-Wei"

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    An enzymatic approach to configurationally rare trans-androsteronyl--glucoside and Its potential anticancerapplication
    (2017-01)
    Chou, Feng-Pai
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    Tsai, Chia-Tse
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    Chiou, Ya-Sheng
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    Chen, Yi-Ju
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    Li, Meng-Erh
    Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl--glucosides. Investigation of trans-androsteronyl--glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl--glucosides with useful biological activities.