Browsing by Author "HU Shang-Hsiu"

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DRUG CARRIER WITH THERMAL SENSITIVITY, MANUFACTURING METHOD THEREOF, AND USE THEREOF
(2012-11-22)
CHEN San-Yuan
;
HU Shang-Hsiu
;
HUANG Hsin-Yang
A drug carrier with thermal sensitivity, a manufacturing method thereof, and a use thereof are disclosed. The drug carrier comprises a nano-magnetic particle, a drug, a composite polymer, and a dense silica shell. The nano-magnetic particle and the drug are encapsulated in the composite polymer which is formed by self-assembly a water-soluble polymer (such as poly vinyl alcohol) and a thermosensitive copolymer (such as Pluronic F68 or Pluronic F127). The stability and drug release of the drug carrier a can be adjusted by combining PVA and thermosensitive copolymer with a different ratio. When an external magnetic field was applied, the cores exhibit significant size shrinkage and the diameter of the drug carrier decreases more than 10 folds due to the change of temperature, which causes burst-like drug release because of shell destruction and physical collapse of the drug carrier.
MAGNETICALLY-CONTROLLABLE NANOMETRIC POROUS DRUG CARRIER
(2013-01-10)
CHEN San-Yuan
;
CHEN Po-Jung
;
LIU Dean-Mo
;
HU Shang-Hsiu
The present invention discloses a magnetically-controllable nanometric porous drug carrier, wherein an organic or inorganic matrix is used to carry the drug, and wherein magnetic nanoparticles having magnetosensitivity are used to encapsulate the surface of the matrix and seal the drug inside the matrix. An external magnetic field is used to control the removal rate of the magnetic nanoparticles and control the behavior and rate of drug release.