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Browsing by Author "Hsieh, Cheng-Ying"

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    Development of nordihydroguaiaretic acid derivatives as potential multidrug-resistant selective agents for cancer treatment
    (2015-01-01)
    Huang, Lin-Chiang Sherlock
    ;
    Chuang, Hong
    ;
    Kapoor, Mohit
    ;
    Hsieh, Cheng-Ying
    ;
    Chou, Shih-Ching
    In this research, we designed and synthesized a new series of nordihydroguaiaretic acid (NDGA) derivatives for multidrug resistance (MDR) research. A methylsulfonyl NDGA derivative, ((2R,3S)-2,3-dimethylbutane-1,4-diyl)bis(benzene-4,1,2-triyl) tetramethanesulfonate (5d), was found to inhibit MDR1 gene expression and suppress drug resistantMES-SA/Dx5 cells. Moreover, the combination of 5d and doxorubicin/terameprocol (M4N) showed a profound synergistic effect on inhibition of drug resistant cancer cells, suggesting that 5d is a potential adjuvant applied with doxorubicin or terameprocol in cancer treatment.