Browsing by Author "Hsieh, Yi-Han"

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Microwave-assisted efficient conjugation of nanodiamond and paclitaxel
(2015-05-15)
Hsieh, Yi-Han
;
Liu, Kuang-Kai
;
Sulake, Rohidas S.
;
Chao, Jui-I.
;
Chen, Chinpiao
Nanodiamond has recently received considerable attention due to the various possible applications in medical field such as drug delivery and bio-labeling. For this purpose suitable and effective surface functionalization of the diamond material are required. A versatile and reproducible surface modification method of nanoscale diamond is essential for functionalization. We introduce the input of microwave energy to assist the functionalization of nanodiamond surface. The feasibility of such a process is illustrated by comparing the biological assay of ND-paclitaxel synthesized by conventional and microwave irradiating. Using a microwave we manage to have approximately doubled grafted molecules per nanoparticle of nanodiamond. (C) 2015 Elsevier Ltd. All rights reserved.
Novel Addressing Method for a Stencil-FSC LCD Based on Human Visual System
(2011)
Lin, Fang-Cheng
;
Huang, Yi-Pai
;
Hsieh, Yi-Han
;
Shieh, Han-Ping D.
;
光電工程學系
According to the human visual system, a novel TFT addressing method is proposed to gain more 85% time for LC response, which makes Stencil-FSC methods more feasible. Two indexes of PDR and relative CBU are introduced to evaluate image difference breakup for an FSC display.
Optimization of gefitinib analogues with potent anticancer activity
(2014-11-15)
Yin, Kai-Hao
;
Hsieh, Yi-Han
;
Sulake, Rohidas S.
;
Wang, Su-Pei
;
Chao, Jui-I.
The interactions of gefitinib (Iressa) in EGFR are hydrogen bonding and van der Waals forces through quinazoline and aniline rings. However the morpholino group of gefitinib is poorly ordered due to its weak electron density. A series of novel piperazino analogues of gefitinib where morpholino group substituted with various piperazino groups were designed and synthesized. Most of them indicated significant anti-cancer activities against human cancer cell lines. In particular, compounds 52-54 showed excellent potency against cancer cells. Convergent synthetic approach has been developed for the synthesis of gefitinib intermediate which can lead to gefitinib as well as numerous analogues. (C) 2014 Elsevier Ltd. All rights reserved.