Browsing by Author "Hsu, Ting-Wei"

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Analysis of the association between transcription factor binding site variants and distinct accompanying regulatory motifs in yeast
(2012-01-10)
Chiang, Sufeng
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Swamy, Krishna B. S.
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Hsu, Ting-Wei
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Tsai, Zing Tsung-Yeh
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Lu, Henry Horng-Shing
It is generally accepted that genes are regulated by the interactions between transcription factors (TFs) and their binding sites (TFBSs). Some studies have demonstrated that nucleotide variants at variable positions in TFBSs affect yeast gene regulation. Furthermore, variable positions in TFBSs in association with distinct accompanying regulatory motifs of other TFs (i.e., co-TFs) can also impact gene regulation in eukaryotes. Given that, even low-affinity IF-DNA interactions are abundant in vivo; we used both low- and high-affinity TFBSs and performed a genome-wide analysis of associations between variable positions and co-TFs. We found that in Saccharomyces cerevisiae, approximately 14% of the variable positions in TFBSs demonstrate such associations. These associations occurred in close proximity on the same promoters (i.e., highly co-localized). Moreover, such associations were highly conserved between sensu stricto yeasts and also influenced gene expression, which were consistent with enriched functional categories. (C) 2011 Elsevier B.V. All rights reserved.
Design and Initial Evaluation of a VR based Immersive and Interactive Architectural Design Discussion System
(2020-01-01)
Hsu, Ting-Wei
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Tsai, Ming-Han
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Babu, Sabarish, V
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Hsu, Pei-Hsien
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Chang, Hsuan-Ming
Design discussion is a very important course in architecture education. In this paper, we developed a VR based architecture design discussion system that allows members to visualize and discuss the architectural models and to modify the models during discussion. Since the system is designed to work on top of Rhinoceros and Grasshopper, the object database is updated right after the object modification. Members communicate via voice, object manipulations, and mid-air sketching as well as on-surface sketching in the virtual environment. Several tools have been designed to enhance the sense of presence and to make the discussion more effective. We also developed a rollback mechanism to help users intuitively and quickly revert to a previous state of discussion to make some changes or to start a new direction of discussion. To evaluate the system, we conducted an initial user study with 14 participants to assess the user experience, user impression and effectiveness of the system. The feedback from participants were positive and suggested that the system could be effective and useful for supporting architecture design discussion.
Immersive VR Environment for Architectural Design Education
(2017-01-01)
Tsou, Chia-Hung
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Hsu, Ting-Wei
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Lin, Chun-Heng
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Tsai, Ming-Han
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Hsu, Pei-Hsien
In tradition architectural design education, instructor and students share and discuss their ideas through drawings and models. Physical models are hard to be modified during discussion, and it is difficult to view the interior spaces. Drawings, including plans, elevations and sections, are generally used as a medium for the purpose of presentation and discussion. We propose an integrated system to support architectural design education, in which multiple users can not only explore and discuss 3D designs in a VR environment, but also manipulate 3D elements. This system also integrates procedural 3D modeling, providing users with the capability of modifying 3D designs in real-time through adjustments of parameters.
Size effect on multiferroic TbMn2O5 nanorods
(2015-05-07)
Yang, Chun-Chuen
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Tung, Yung-Hsiang
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Chen, Yi-Jung
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Hsu, Ting-Wei
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You, Pang-Yen
The effect of the size of TbMn2O5 on their magnetoelectric properties is studied using a field emission transmission electron microscope, ac magnetic susceptibility, relative dielectric constant, specific heat capacity, and x-ray diffraction at various temperatures. A bulk sample and nanorods with two axial lengths, < L-C >, are investigated. Nanorods with < L-C > of 216 nm and 64 nm crystallize with orthorhombic Pbam symmetry as the bulk material. The axial direction of the two sizes of nanorod is parallel to the c axis of the crystal. No particular radial direction is observed. The critical size for the magnetic ordering of TbMn2O5 is found to be between < L-C > - 64 nm and 216 nm. Experiments on specific heat capacity verified these results. No similar phenomenon concerning the ferroelectric property is observed. At T = 30K and 35 K, the < L-C > - 216 nm sample yields a charge-ordering-like x-ray diffraction peak, which may be associated with the magnetically induced charge ordering superlattice. (C) 2015 AIP Publishing LLC.