<link rel="stylesheet" href="styles.cf390c6bfbe7555f.css">

Browsing by Author "Hsu, Wen-Chen"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item type:Item,
    Pregnenolonyl-alpha-glucoside exhibits marked anti-cancer and CYP17A1 enzymatic inhibitory activities
    (2020-02-07)
    Chou, Feng-Pai
    ;
    Hsu, Wen-Chen
    ;
    Huang, Sheng-Cih
    ;
    Chang, Chin-Yuan
    ;
    Chiou, Ya-Sheng
    We report here that pregnenolonyl-alpha-glucoside (2), a steryl glycoside synthesized directly from pregnenolone and glucose via a consecutive multienzyme-catalyzed process, exhibits marked dose-dependent cytotoxic activity against HT29, AGS, and ES-2 cells with IC50 values of 23.5 to 50.9 mu M. An in vitro CYP17A1 binding pattern assay and protein-ligand docking model support that 2, like abiraterone, binds in the active site heme iron pocket of CYP17A1.