Browsing by Author "Huang, C. -H."

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Brain nociceptive imaging in rats using F-18-fluorodeoxyglucose small-animal positron emission tomography
(2008-09-09)
Shih, Y. -Y. I.
;
Chiang, Y. -C.
;
Chen, J. -C.
;
Huang, C. -H.
;
Chen, Y. -Y.
Preclinical exploration of pain processing in the brain as well as evaluating pain-relief drugs in small animals embodies the potential biophysical effects in humans. However, it is difficult to measure nociception-related cerebral metabolic changes in vivo, especially in unanesthetized animals. The present study used F-18-fluorodeoxyglucose small-animal positron emission tomography to produce cerebral metabolic maps associated with formalin-induced nociception. Anesthesia was not applied during the uptake period so as to reduce possible confounding effects on pain processing in the brain. The formalin stimulation at the hind paw of rats resulted in significant metabolic increases in the bilateral cingulate cortex, motor cortex, primary somatosensory cortex, secondary somatosensory cortex, insular cortex, visual cortex, caudate putamen, hippocampus, periaqueductal gray, amygdala, thalamus, and hypothalamus. Among the measured areas, clear lateralization was only evident in the primary somatosensory cortex and hypothalamus. In addition, pretreatment with lidocaine (4 mg/kg, i.v.) and morphine (10 mg/kg, i.v.) significantly suppressed formalin-induced cerebral metabolic increases in these areas. The present protocol allowed identification of the brain areas involved in pain processing, and should be useful in further evaluations of the effects of new drugs and preclinical therapies for pain. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.
Photoinduced hydrophilicity of TiO(2) film as the effect of H(2)O(2) addition
(2010-04-01)
Tseng, Y. -H.
;
Kuo, C. -S.
;
Huang, C. -H.
;
Hirakawa, T.
;
Negishi, N.
TiO(2) thin film photocatalysts coated onto glass plates were prepared by thermal decomposition of tetraisopropyl orthotitanate with a dip-coating process. In this Letter, the mechanism for photoinduced hydrophilicity of TiO(2) film is clarified by adding the extra H(2)O(2) on TiO(2) surface. Results show that the photoinduced hydrophilicity of TiO(2) film is inhibited with the presence of H(2)O(2). The amount of Ti-OH bonds on the surface oppositely increased by the addition of H(2)O(2). It indicates the photoinduced hydrophilicity of TiO(2) results from surface oxygen vacancy, not Ti-OH bonds.
Photoinduced hydrophilicity of TiO2 film as the effect of H2O2 addition
(2010-04-01)
Tseng, Y. -H.
;
Kuo, C. -S.
;
Huang, C. -H.
;
Hirakawa, T.
;
Negishi, N.
TiO2 thin film photocatalysts coated onto glass plates were prepared by thermal decomposition of tetraisopropyl orthotitanate with a dip-coating process. In this Letter, the mechanism for photoinduced hydrophilicity of TiO2 film is clarified by adding the extra H2O2 on TiO2 surface. Results show that the photoinduced hydrophilicity of TiO2 film is inhibited with the presence of H2O2. The amount of Ti-OH bonds on the surface oppositely increased by the addition of H2O2. It indicates the photoinduced hydrophilicity of TiO2 results from surface oxygen vacancy, not Ti-OH bonds.