Browsing by Author "Huang, Cheng-Yang"

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Deformation Simulation Based on Model Reduction with Rigidity Sampling
(2017-01-01)
Chien, Shuo-Ting
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Hu, Chen-Hui
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Huang, Cheng-Yang
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Tsai, Yu-Ting
;
Lin, Wen-Chieh
Deformation simulation based on model reduction with rigidity-guided sampling
(2018-06-01)
Chien, Shuo-Ting
;
Hu, Chen-Hui
;
Huang, Cheng-Yang
;
Tsai, Yu-Ting
;
Lin, Wen-Chieh
The deformation results of previous model reduction methods with external forces applied show noticeable differences from full-scale finite element method (FEM) simulation. We found that data-driven approaches, specifically proper orthogonal decomposition, can be a solution to this nonlinear deformation simulation problem in the subspace. Nevertheless, off-line FEM simulation with an infinite number of possible input forces at different locations makes it infeasible if no prior information is given. We propose rigidity-guided sampling to efficiently select the points of application of forces (force sample points) to construct more effective and compact subspace bases, thereby improving the simulation accuracy of reduced deformable models with applied external forces and still retaining fast run-time performance. The key idea of our approach is that distinct deformations of an object at different force sample points can be estimated prior to FEM simulation. By selecting the force sample points with distinct deformations, the computational cost of off-line FEM simulation can be reduced significantly. Our run-time deformation results are much closer to the full-scale FEM simulation with external forces applied, compared to the results of using only the modal derivative bases while the speedup over full-scale simulation is still substantial.
Design of a finger base-type pulse oximeter
(2016-01-01)
Lin, Bor-Shyh
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Huang, Cheng-Yang
;
Chen, Chien-Yue
;
Lin, Jiun-Hung
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影像與生醫光電研究所
A pulse oximeter is a common medical instrument used for noninvasively monitoring arterial oxygen saturation (SpO(2)). Currently, the fingertip-type pulse oximeter is the prevalent type of pulse oximeter used. However, it is inconvenient for long-term monitoring, such as that under motion. In this study, a wearable and wireless finger base-type pulse oximeter was designed and implemented using the tissue optical simulation technique and the Monte Carlo method. The results revealed that a design involving placing the light source at 135 degrees-165 degrees and placing the detector at 75 degrees-90 degrees or 90 degrees-105 degrees yields the optimal conditions for measuring SpO(2). Finally, the wearable and wireless finger base-type pulse oximeter was implemented and compared with the commercial fingertip-type pulse oximeter. The experimental results showed that the proposed optimal finger base-type pulse oximeter design can facilitate precise SpO(2) measurement. (C) 2016 AIP Publishing LLC.
Design of a finger base-type pulse oximeter
(2016-01)
Lin, Bor-Shyh
;
Huang, Cheng-Yang
;
Chen, Chien-Yue
;
Lin, Jiun-Hung
;
影像與生醫光電研究所
A pulse oximeter is a common medical instrument used for noninvasively monitoring arterial oxygen saturation (SpO(2)). Currently, the fingertip-type pulse oximeter is the prevalent type of pulse oximeter used. However, it is inconvenient for long-term monitoring, such as that under motion. In this study, a wearable and wireless finger base-type pulse oximeter was designed and implemented using the tissue optical simulation technique and the Monte Carlo method. The results revealed that a design involving placing the light source at 135 degrees-165 degrees and placing the detector at 75 degrees-90 degrees or 90 degrees-105 degrees yields the optimal conditions for measuring SpO(2). Finally, the wearable and wireless finger base-type pulse oximeter was implemented and compared with the commercial fingertip-type pulse oximeter. The experimental results showed that the proposed optimal finger base-type pulse oximeter design can facilitate precise SpO(2) measurement. (C) 2016 AIP Publishing LLC.
Effect of metal binding and posttranslational lysine carboxylation on the activity of recombinant hydantoinase
(2009-01-01)
Huang, Cheng-Yang
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Hsu, Ching-Chen
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Chen, Mei-Chun
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Yang, Yuh-Shyong
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生物科技學系
Bacterial hydantoinase possesses a binuclear metal center in which two metal ions are bridged by a posttranslationally carboxylated lysine. How the carboxylated lysine and metal binding affect the activity of hydantoinase was investigated. A significant amount of iron was always found in Agrobacterium radiobacter hydantoinase purified from unsupplemented cobalt-, manganese-, or zinc-amended Escherichia coli cell cultures. A titration curve for the reactivation of apohydantoinase with cobalt indicates that the first metal was preferentially bound but did not give any enzyme activity until the second metal was also attached to the hydantoinase. The pH profiles of the metal-reconstituted hydantoinase were dependent on the specific metal ion bound to the active site, indicating a direct involvement of metal in catalysis. Mutation of the metal binding site residues, H57A, H59A, K148A, H181A, H237A, and D313A, completely abolished hydantoinase activity but preserved about half of the metal content, except for K148A, which lost both metals in its active site. However, the activity of K148A could be chemically rescued by short-chain carboxylic acids in the presence of cobalt, indicating that the carboxylated lysine was needed to coordinate the binuclear ion within the active site of hydantoinase. The mutant D313E enzyme was also active but resulted in a pH profile different from that of wild-type hydantoinase. A mechanism for hydantoinase involving metal, carboxylated K148, and D313 was proposed.
Near-infrared Spectroscopy System for Determining Brain Hemoglobin Level
(2013)
Wu, Pei-Jung
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Chang, Ming-Hsien
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Huang, Cheng-Yang
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Wang, Yu-Cheng
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Kuo, Jinn-Rung
Traumatic brain injury (TBI) usually results from brain shaking or impact. It can affect the normal function of the brain and even cause people become disabled and death. However, there is lack of studies for the physiological changes of humans or animals under brain injury. In order to obtain the information of physiological state change, we designed and enforced a non-invasive, wireless multi-channel near-infrared spectroscopy (NIRS) for monitoring the concentration change of oxy-hemoglobin (HbO(2)), deoxy-hemoglobin (HbR) and total-hemoglobin (HbT) continuously during and after TBI. The experimental results indicated that the concentration change of HbO(2) and HbT is significantly related to the impact strength and infarction volume. Thus, this system is easily used and stable for TBI study.
Novel Wearable and Wireless Ring-Type Pulse Oximeter with Multi-Detectors
(2014-09-01)
Huang, Cheng-Yang
;
Chan, Ming-Che
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Chen, Chien-Yue
;
Lin, Bor-Shyh
;
影像與生醫光電研究所
The pulse oximeter is a popular instrument to monitor the arterial oxygen saturation (SPO2). Although a fingertip-type pulse oximeter is the mainstream one on the market at present, it is still inconvenient for long-term monitoring, in particular, with respect to motion. Therefore, the development of a wearable pulse oximeter, such as a finger base-type pulse oximeter, can effectively solve the above issue. However, the tissue structure of the finger base is complex, and there is lack of detailed information on the effect of the light source and detector placement on measuring SPO2. In this study, the practicability of a ring-type pulse oximeter with a multi-detector was investigated by optical human tissue simulation. The optimal design of a ring-type pulse oximeter that can provide the best efficiency of measuring SPO2 was discussed. The efficiency of ring-type pulse oximeters with a single detector and a multi-detector was also discussed. Finally, a wearable and wireless ring-type pulse oximeter was also implemented to validate the simulation results and was compared with the commercial fingertip-type pulse oximeter.