Browsing by Author "Huang, Chun-Chi"

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Differences in Mortality and Clinical Manifestations of Dengue Hemorrhagic Fever in Taiwan in Different Years: A Comparison for Cases in 2014 and 2015 Epidemics
(2017-01-01)
Chang, Ko
;
Huang, Chung-Hao
;
Lee, Ing-Kit
;
Lu, Po-Liang
;
Lin, Chun-Yu
People in southern Taiwan experienced two major dengue outbreaks in 2014 and 2015. The mortality and clinical features were very different between these 2 years. Dengue virus serotype 1 (DENV-1) caused epidemic outbreak in 2014 and DENV-2 was predominant in 2015. The characteristics of dengue hemorrhagic fever (DHF) cases in the 2 years was analyzed. We conducted a retrospective chart review to analyze the clinical and laboratory features of 206 adult patients with DHF in southern Taiwan in 2014 and 2015. The mortality rate of DHF cases in 2015 was higher than that of cases in 2014 (38.7% versus 12.4%, P < 0.0001). Compared with cases in 2014, DHF cases in 2015 had more complications, such as gastrointestinal bleeding (78.5% versus 61.9%, P = 0.01), severe hepatitis (30.1% versus 8%, P < 0.0001), and myocarditis (14% versus 0.9%, P < 0.0001). Among the mortality cases, diabetes, chronic renal failure, proton-pump inhibitors using, platelet transfusion, and Charlson comorbidity index score (Charlson score) were also higher in 2015. Multivariate analysis for the mortality cases revealed that the risk factors were Charlson score (3) 5 (P = 0.02, odds ratio [OR] = 4.07, 95% confidence interval [CI] = 1.244-13.307), severe hepatitis (P < 0.0001, OR = 11.97, 95% CI = 3.831-37.396), and acute renal failure (P < 0.0001, OR = 98.76, 95% CI = 10.847-899.22). DHF cases in 2015 had higher mortality and more complications, such as gastrointestinal bleeding, severe hepatitis, and myocarditis, than in 2014 in southern Taiwan. In the 2-year DHF case series, Charlson score >= 5, severe hepatitis, and acute renal failure were independent significant variables for mortality.
EagleEye: Towards Mandatory Security Monitoring in Virtualized Datacenter Environment
(2013)
Wu, Yu-Sung
;
Sun, Pei-Keng
;
Huang, Chun-Chi
;
Lu, Sung-Jer
;
Lai, Syu-Fang
Virtualized datacenter (VDC) has become a popular approach to large-scale system consolidation and the enabling technology for infrastructure-as-a-service cloud computing. The consolidation inevitably aggregates the security threats once faced by individual systems towards a VDC, and a VDC operator should remain vigilant of the threats at all times. We envision the need for on-demand mandatory security monitoring of critical guest systems as a means to track and deter security threats that could jeopardize the operation of a VDC. Unfortunately, existing VDC security monitoring mechanisms all require pre-installed guest components to operate. The security monitoring would either be up to the discretion of individual tenants or require costly direct management of guest systems by the VDC operator. We propose the EagleEye approach for on-demand mandatory security monitoring in VDC environment, which does not depend on pre-installed guest components. We implement a prototype on-access anti-virus monitor to demonstrate the feasibility of the EagleEye approach. We also identify challenges particular to this approach, and provide a set of solutions meant to strengthen future research in this area.
IL-28 and IL-29 as protective markers in subject with dengue fever
(2017-06-01)
Hung, Chih-Hsing
;
Huang, Chung-Hao
;
Wang, Lin
;
Huang, Chun-Chi
;
Wu, Meng-Chieh
About 400 million people every year are estimated to contract dengue virus infection, which causes prolonged morbidity and sometimes mortality. Interleukin (IL)-28 and IL-29 are relatively newly discovered cytokines and play an important role in our immune defense against pathogens, especially for viral infection. In the present study, we investigated serum IL-28 and IL-29 expression and the relationship to clinical and laboratory parameters in patients with dengue virus infection. Adult patients with dengue (n = 45) and control group (n = 24) were included prospectively. Clinical symptoms and laboratory data were collected from every patient. We investigated IL-28 and IL-29 levels in serum by ELISA. The concentrations of serum IL-28 and IL-29 were significantly higher in subjects with dengue when compared to those of control group. The patients with higher serum IL-28 and IL-29 levels had significantly lower ALAT and peripheral blood neutrophil percentage, but higher peripheral platelet, total white blood cell (WBC), monocyte, and lymphocyte counts. Patients with higher serum IL-28 and IL-29 levels also had more flu-like symptoms, but less vomiting. Increased level of IL-28 and IL-29 was associated with better liver function, platelet and WBC numbers and clinical symptom in subjects with dengue and could potentially serve as a protective marker.