Browsing by Author "Huang, Hsu-Wen"

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AGE-RELATED AND INDIVIDUAL DIFFERENCES IN ENTROPY-BASED COMPLEXITY OF HEALTHY AGING BRAIN
(2019-09-01)
Huang, Chih-Mao
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Fang, Ya-Wen
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Chen, Guan-Yen
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Tzeng, Ovid J. L.
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Huang, Hsu-Wen
Aging, cognition, and the brain: effects of age-related variation in white matter integrity on neuropsychological function
(2019-07-03)
Fan, Yang-Teng
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Fang, Ya-Wen
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Chen, Ya-Ping
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Leshikar, Eric D.
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Lin, Ching-Po
Alterations in brain structure are viewed as neurobiological indicators which are closely tied to cognitive changes in healthy human aging. The current study used diffusion tensor imaging (DTI) tractography to investigate the relationship between age, brain variation in white matter (WM) integrity, and cognitive function. Sixteen younger adults (aged 20-28 years) and 18 healthy older adults (aged 60-75 years) underwent DTI scanning and a standardized battery of neuropsychological measures. Behaviorally, older adults exhibited poorer performance on multiple cognitive measures compared to younger adults. At the neural level, the effects of aging on theWM integrity were evident within interhemispheric (the anterior portion of corpus callosum) and transverse (the right uncinate fasciculus) fibers of the frontal regions, and the cingulum-angular fibers. Our correlation results showed that age-related WM differentially influenced cognitive function, with increased fractional anisotropy values in both the anterior corpus callosum and the right cingulum/angular fibers positively correlated with performance on the visuospatial task in older adults. Moreover, mediation analysis further revealed that the WM tract integrity of the frontal interhemspheric fibers was a significant mediator of age-visuospatial performance relation in older adults, but not in younger adults. These findings support the vulnerability of the frontal WM fibers to normal aging and push forward our understanding of cognitive aging by providing a more integrative view of the neural basis of linkages among aging, cognition, and brain.
Aging, neurocognitive reserve, and the healthy brain
(2019-01-01)
Huang, Chih-Mao
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Huang, Hsu-Wen
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生物科技學系
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Department of Biological Science and Technology
Healthy older adults experience a general decrement in physical and cognitive abilities with advancing age. The severity of these behavioral and neurocognitive declines is highly variable within the aged population. The Neurocognitive Reserve Hypothesis has been proposed in the cognitive and clinical neuroscience of aging to suggest that mentally-stimulating activities and life-long experiences may provide reserve-a protective mechanism that increases the brain's capacity to cope with age-related pathology. This model of the neurocognitive reserve hypothesis has successfully provided a theoretical account for the disjunction between the degree of observed brain damage/pathology and the clinical manifestations of that damage, both structurally and functionally. This article briefly reviews the behavioral and neuroimaging evidence that neurocognitive reserve shapes age-related and individual differences in neurocognitive processes, patterns of neural activation, brain structures and neural networks. Moreover, existing theoretical frameworks proposed in the aging literature are introduced to complement the understanding of neurocognitive reserve in normal and pathological aging. Finally, we report preliminary functional and structural neuroimaging results to support the hypothesis that neurocognitive reserve is a neural resource that mitigates not only the effects of cognitive decline caused by neurological diseases and/or psychiatric disorders, but also those caused by the general aging process. We conclude that there is currently limited understanding of the mechanisms underlying neurocognitive reserve; however, the concept provides a dynamic view for understanding the nature of resilience and our ability to adapt as we age to cope with brain pathology and damage. Future studies may consider decoding the individualized factors potentially underpinning neurocognitive reserve's beneficial contribution to protecting against accelerated cognitive decline and to promoting psychological resilience with advanced aging.
AN EVENT-RELATED POTENTIAL STUDY OF COGNITIVE LOAD AND CONFLICT RESOLUTION IN NUMERICAL STROOP TASK
(2015-09-01)
Huang, Chih-Mao
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Wang, Ya-Yi
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Huang, Pei-Shan
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Huang, Hsu-Wen
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交大名義發表
AUDITORY SENTENCE COMPREHENSION: SENTENTIAL CONSTRAINT EFFECTS ON WORD PROCESSING
(2015-09-01)
Wang, Ya-Yi
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Tzeng, Ovid J. -L.
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Huang, Hsu-Wen
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交大名義發表
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National Chiao Tung University
BRAIN SIGNATURE OF SUBJECTIVE PERFORMANCE DURING NUMERICAL STROOP TASKS
(2019-09-01)
Huang, Hsu-Wen
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Nascimben, Mauro
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Fong, Dong-Yang
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Tzeng, Ovid J. L.
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Huang, Chih-Mao
Culture-Related and Individual Differences in Regional Brain Volumes: A Cross-Cultural Voxel-Based Morphometry Study
(2019-09-10)
Huang, Chih-Mao
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Doole, Robert
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Wu, Changwei W.
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Huang, Hsu-Wen
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Chao, Yi-Ping
Converging behavioral and functional neuroimaging evidence indicates that East Asian and Western individuals have different orientations for processing information that may stem from contrasting cultural values. In this cross-cultural magnetic resonance imaging (MRI) study, we used voxel-based morphometry (VBM) approach to investigate culture-related and individual differences of independent-interdependent orientation in structural brain volume between 57 Taiwanese and 56 Western participants. Each participant's degree of endorsement of independent and interdependent cultural value was assessed by their self-report on the Singelis Self-Construal Scale (SCS). Behaviorally, Taiwanese rated higher SCS scores than Westerners in interdependent value and Westerners rated higher SCS scores than Taiwanese in independent value. The VBM results demonstrated that Western participants showed greater gray matter (GM) volume in the fronto-parietal network, whereas Taiwanese participants showed greater regional volume in temporal and occipital regions. Our findings provide supportive evidence that socio-cultural experiences of learned independent-interdependent orientations may play a role in regional brain volumes. However, strategic differences in cognition, genetic variation, and/or modulations of other environmental factors should also be considered to interpret such culture-related effects and potential individual differences.
NEURAL CORRELATES OF CONVERGENT AND DIVERGENT CREATIVITY: AN FMRI STUDY
(2017-12-01)
Tseng, De-Jung
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Wu, Changwei
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Liu, Meichun
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Huang, Hsu-Wen
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Huang, Chih-Mao