Browsing by Author "Huang, Yu-Chieh"

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2.5D Heterogeneously Integrated Microsystem for High-Density Neural Sensing Applications
(2014-12-01)
Huang, Po-Tsang
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Wu, Shang-Lin
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Huang, Yu-Chieh
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Chou, Lei-Chun
;
Huang, Teng-Chieh
Heterogeneously integrated and miniaturized neural sensing microsystems are crucial for brain function investigation. In this paper, a 2.5D heterogeneously integrated bio-sensing microsystem with mu-probes and embedded through-silicon-via (TSVs) is presented for high-density neural sensing applications. This microsystem is composed of mu-probes with embedded TSVs, 4 dies and a silicon interposer. For capturing 16-channel neural signals, a 24 x 24 mu-probe array with embedded TSVs is fabricated on a 5 x 5 mm2 chip and bonded on the back side of the interposer. Thus, each channel contains 6 x 6 mu-probes with embedded TSVs. Additionally, the 4 dies are bonded on the front side of the interposer and designed for biopotential acquisition, feature extraction and classification via low-power analog front-end (AFE) circuits, area-power-efficient analog-to-digital converters (ADCs), configurable discrete wavelet transforms (DWTs), filters, and a MCU. An on-interposer bus (mu-SPI) is designed for transferring data on the interposer. Finally, the successful in-vivo test demonstrated the proposed 2.5D heterogeneously integrated bio-sensing microsystem. The overall power of this microsystem is only 676.3 mu W for 16-channel neural sensing.
A +/- 6ms-Accuracy, 0.68mm(2) and 2.21 mu W QRS Detection ASIC
(2010)
Wang, Hui-Min
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Lai, You-Liang
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Hou, Mark C.
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Lin, Shih-Hsiang
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Yen, Brad S.
Healthcare issues arose from population aging. Meanwhile, electrocardiogram (ECG) is a powerful measurement tool. The first step of ECG is to detect QRS complexes. A state-of-the-art QRS detection algorithm was modified and implemented. By the dedicated architecture design, the novel ASIC is proposed with 2.21 mu W power consumption and 0.68mm(2) core area. It is the smallest QRS detection ASIC so far in the world. In addition, the positive prediction of the ASIC is 99.36% based on the MIT/BIH arrhythmia database certification.
A 100 MHZ 1920x1080 HD-PHOTO 20 FRAMES/SEC JPEG XR ENCODER DESIGN
(2008)
Chien, Ching-Yen
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Huang, Sheng-Chieh
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Lin, Shih-Hsiang
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Huang, Yu-Chieh
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Chen, Yi-Cheng
A JPEG XR chip for HD-Photo is implemented with 25 MM area in TSMC 0.18um CMOS 1P6M technology at 100MHz According to the simulation results, the 4:4:4 1920x1080 HD-Photo 20 frames/sec can be encoded smoothly.
A 64-CHANNEL WIRELESS NEURAL SENSING MICROSYSTEM WITH TSV-EMBEDDED MICRO-PROBE ARRAY FOR NEURAL SIGNAL ACQUISITION
(2017-01-01)
Huang, Yu-Chieh
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Huang, Po-Tsang
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Hu, Yu-Chen
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Wu, Shang-Lin
;
You, Yan-Huei
To enhance the signal integrity of high-density neural-sensing signals, this work presents an implantable high spatial resolution mu-probe array with through-silicon via (TSV) 2.5D integration technology that realizes a miniaturized implantable device on flexible printed circuit (FPC) interposer. The proposed microsystem was composed of two 32-channel neural sensing chips and one radio frequency chip for neural signal processing. The mu-probe array can achieve better signal-to-noise ratio with neural-signal acquisition and processing circuit composed of a pseudo-resistor-based analog front-end amplifier. Moreover, a receiving antenna is also implemented on the backside of FPC for wireless data and power transmission. The feasibility of the proposed mu-probe array, Tx and Rx antenna, 32-channel neural sensing circuits in the 64-channel wireless microsystem have been successfully demonstrated for future integration and animal experiments.
A BIOMEDICAL ENTERTAINMENT PLATFORM DESIGN BASED ON MUSICAL RHYTHM CHARACTERISTICS AND HEART RATE VARIABILITY (HRV)
(2008)
Huang, Yu-Chieh
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Lin, Shih-Hsiang
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Chien, Ching-Yen
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Chen, Yi-Cheng
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Chou, Lei-Chun
Heart rate variability (HRV) is a measure of variations in the heart rate. Over the last 25 years, HRV analysis has became popular as a non-invasive research and clinical tool for indirectly investigating both cardiac and autonomic nervous system (ANS) function in both health and disease area. How the musical rhythmic characteristics, tempo and complexity, affect the performance of HRV is studied in this work. By understanding the relationship between music and the function of ANS, the novel biomedical entertainment platform is proposed and used for relaxation.
A capacitor-based sensor and a contact lens sensing system for intraocular pressure monitoring
(2016-01-01)
Chiou, Jin-Chern
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Huang, Yu-Chieh
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Yeh, Guan-Ting
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電機資訊學士班
;
電控工程研究所
This study proposes a capacitor-based sensor on a soft contact lens for the measurement of intraocular pressure (IOP). The sensor was designed and fabricated via microelectromechanical system fabrication technologies. The soft contact lens is designed to be worn on a cornea such that the curvature of the contact lens corresponds substantially to that of the cornea. In addition, the contact lens was fabricated via a cast-molding method using poly-2-hydroxyethyl methacrylate to achieve a lens with high oxygen permeability, which can be worn comfortably for a long time. An IOP sensor prototype was implemented, which exhibited 1.2239 pF mmHg(-1) (13,171 ppm mmHg(-1)) sensitivity during measurements of an artificial anterior chamber at pressures between 18 and 30 mmHg. The results indicate that the developed capacitor-based IOP sensor exhibited high stability and reproducibility in a series of measurements performed under various pressures. The capacitance of the proposed IOP sensor can successfully be converted into a digital value via a capacitor-to-digital converter and be transmitted via a commercial wireless telemetry system in this study.
A Computational Model of the Relationship Between Musical Rhythm and Heart Rhythm
(2009)
Wang, Hui-Min
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Lin, Shih-Hsiang
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Huang, Yu-Chieh
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Chen, I-Cheng
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Chou, Lei-Chun
Heart rate variability (HRV) is a measure of variation in the heart rate. Over the last 25 years, HRV analysis has became utilized more often as a non-invasive research and clinical tool for indirectly investigating both cardiac and autonomic nervous system (ANS) functions in health and disease. In our experiment, 22 healthy subjects and four testing rhythm patterns are studied. How the three musical-rhythmic characteristics of tempo, complexity and drum sample affect the performance of HRV is discussed and a computational model with four factors is proposed. This relationship can help us to improve our life and health by music.
A Contact Lens Sensor System with a Micro-Capacitor for Wireless Intraocular Pressure Monitoring
(2013)
Huang, Yu-Chieh
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Yeh, Guan-Ting
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Yang, Tzu-Sen
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Chiou, Jin-Chern
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電控工程研究所
This paper proposes a novel micro-capacitor sensor for intraocular pressure (IOP) measurement on soft contact lens. The sensor was designed and fabricated by using MEMS fabrication technologies. The contact lens is for wearing on a cornea such that a curvature of the contact lens corresponds substantially to that of the cornea, and is preferably made of Hydroxyethylmethacrylate (HEMA) by cast-molding method of soft contact lens for high oxygen permeability and comfortable long-duration wearing. The prototype without wireless antenna has been implemented with a sensitivity of 0.43 pF/mmHg in measurement of human eye like balloon pressure test between 100 mmHg and 180 mmHg. The results show its high stability and reproducibility in a series of repeatable pressure variation. In future work the micro-capacitor will be tested on enucleated porcine eyes with better and integrated with a radio frequency integrated circuit and antenna on soft contact lens so that IOP value could be transferred to voltage value via capacitor to voltage converter and transmits IOP sensing signal by wireless telemetry system.
A Novel Pseudo Resistor Structure for Biomedical Front-end Amplifiers
(2015)
Huang, Yu-Chieh
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Yang, Tzu-Sen
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Hsu, Shun-Hsi
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Chen, Xin-Zhuang
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Chiou, Jin-Chern
This study proposes a novel pseudo resistor structure with a tunable DC bias voltage for biomedical front-end amplifiers (FEAs). In the proposed FEA, the high-pass filter composed of differential difference amplifier and a pseudo resistor is implemented. The FEA is manufactured by using a standard TSMC 0.35 mu m CMOS process. In this study, three types FEAs included three different pseudo resistor are simulated, fabricated and measured for comparison and electrocorticography (ECoG) measurement, and all the results show the proposed pseudo resistor is superior to other two types in bandwidth. In chip implementation, the lower and upper cutoff frequencies of the high-pass filter with the proposed pseudo resistor are 0.15 Hz and 4.98 KHz, respectively. It also demonstrates lower total harmonic distortion performance of -58 dB at 1 kHz and higher stability with wide supply range (1.8 V and 3.3 V) and control voltage range (0.9 V and 1.65 V) than others. Moreover, the FEA with the proposed pseudo successfully recorded spike-and-wave discharges of ECoG signal in in vivo experiment on rat with pentylenetetrazol-induced seizures.
A study of the relationship between two musical rhythm characteristics and heart rate variability (HRV)
(2008)
Lin, Shih-Hsiang
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Huang, Yu-Chieh
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Chien, Ching-Yen
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Chen, Yi-Cheng
;
Chou, Lei-Chun
Heart rate variability (HRV) is a measure of variations in the heart rate. Over the last 25 years, HRV analysis has became more and more popular as a non-invasive research and clinical tool for indirectly investigating both cardiac and autonomic nervous system (ANS) function in both health and disease area. How the musical rhythmic characteristics, tempo and complexity, affect the performance of HRV is studied in this work. By understanding the relationship between music and the function of ANS, we can improve our life and health by music - non-invasively and simply.
A Wirelessly Powered Smart Contact Lens with Reconfigurable Wide Range and Tunable Sensitivity Sensor Readout Circuitry
(2017-01-01)
Chiou, Jin-Chern
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Hsu, Shun-Hsi
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Huang, Yu-Chieh
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Yeh, Guan-Ting
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Liou, Wei-Ting
This study presented a wireless smart contact lens system that was composed of a reconfigurable capacitive sensor interface circuitry and wirelessly powered radio-frequency identification (RFID) addressable system for sensor control and data communication. In order to improve compliance and reduce user discomfort, a capacitive sensor was embedded on a soft contact lens of 200 mu m thickness using commercially available bio-compatible lens material and a standard manufacturing process. The results indicated that the reconfigurable sensor interface achieved sensitivity and baseline tuning up to 120 pF while consuming only 110 mu W power. The range and sensitivity tuning of the readout circuitry ensured a reliable operation with respect to sensor fabrication variations and independent calibration of the sensor baseline for individuals. The on-chip voltage scaling allowed the further extension of the detection range and prevented the implementation of large on-chip elements. The on-lens system enabled the detection of capacitive variation caused by pressure changes in the range of 2.25 to 30 mmHg and hydration level variation from a distance of 1 cm using incident power from an RFID reader at 26.5 dBm.
An Advanced 2.5-D Heterogeneous Integration Packaging for High-Density Neural Sensing Microsystem
(2017-04-01)
Hu, Yu-Chen
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Huang, Yu-Chieh
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Huang, Po-Tsang
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Wu, Shang-Lin
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Chang, Hsiao-Chun
In the traditional neural sensing microstructure, the limited metal line pitch and the metal layer numbers restrict the neural signal routing ability from electrodes to circuit chips. Miniature packaging and excessive noise interference bottlenecks are some of the challenges faced by the electrodes and circuit chips integration with traditional wire bonding. This paper proposes a 2.5-D heterogeneous integration neural sensing microsystem based on the silicon substrate to overcome these issues. With standard semiconductor and 3-D integration processes, high-channel-density (256 channels at 25 mm(2)) neural sensing microsystem is achieved. Through silicon via provides the shortest vertical interconnection and dramatically minimizes the packaging. Furthermore, the interposer can carry multiple chips to enhance the function of the biosensor. Electrical characteristics and reliability examinations reveal its high quality and great performance as compared to traditional approaches. This novel highly integrated neural sensing microsystem is expected to contribute to the biomedical field for exploring and solving unknown biological mysteries.
An Implantable 128-Channel Wireless Neural-Sensing Microsystem using TSV-Embedded Dissolvable mu-Needle Array and Flexible Interposer
(2017-01-01)
Huang, Po-Tsang
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Huang, Yu-Chieh
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Wu, Shang-Lin
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Hu, Yu-Chen
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Lu, Ming-Wei
For implanted neural-sensing devices, one of the remaining challenges is to transmit stable power/data (P/D) transmission for high spatiotemporal resolution neural data. This paper presents a miniaturized implantable 128-channel wireless neural-sensing microsystem using TSV-embedded dissolvable mu-needle array, a flexible interposer and 4 dies by 2.5D/3D TSV heterogeneous SiP technology. The 4 dies are 2 neural-signal acquisition ICs implemented by 90nm CMOS, 1 neural-signal processor by 40nm CMOS and 1 wireless P/D transmission circuitry by 0.18 mu m CMOS. Thus, the proposed wireless microsystem realizes 128-channel neural-signal sensing within the area of 5mm x 5mm, neural feature extraction and wireless P/D transmission using an on-interposer inductor. The overall average power of the circuits in this microsystem is only 9.85mW.
An RFID-based On-lens Sensor System for Long-Term IOP Monitoring
(2015)
Hsu, Shun-Hsi
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Chiou, Jin-Chern
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Liao, Yu-Te
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Yang, Tzu-Sen
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Kuei, Cheng-Kai
In this paper, an RFID-based on-lens sensor system is proposed for noninvasive long-term intraocular pressure monitoring. The proposed sensor IC, fabricated in a 0.18um CMOS process, consists of capacitive sensor readout circuitry, RFID communication circuits, and digital processing units. The sensor IC is integrated with electroplating capacitive sensors and a receiving antenna on the contact lens. The sensor IC can be wirelessly powered, communicate with RFID compatible equipment, and perform IOP measurement using on-lens capacitive sensor continuously from a 2cm distance while the incident power from an RFID reader is 20 dBm. The proposed system is compatible to Gen2 RFID protocol, extending the flexibility and reducing the self-developed firmware efforts.
An Ultra-High-Density 256-channel/25mm(2) Neural Sensing Microsystem using TSV-embedded Neural Probes
(2016)
Huang, Yu-Chieh
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Huang, Po-Tsang
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Wu, Shang-Lin
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Hui, Yu-Chen
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You, Yan-Huei
Highly integrated neural sensing microsystems are crucial to capture accurate signals for brain function investigations. In this paper, a 256-channel/25 mm(2) neural sensing microsystem is presented based on through-silicon-via (TSV) 2.5D integration. This microsystem composes of dissolvable mu-needles, TSV-embedded mu-probes, 256-channel neural amplifiers, 11-bit area-power-efficient SAR ADCs and serializers. Based on the dissolvable mu-needles and TSV 2.5D integration, this microsystem can detect 256 ECoG/LFP signals within the small area of 5mm x 5mm. Additionally, the neural amplifier realizes 57.8dB gain with only 9.8 mu W for each channel, and the 9.7-bit ENOB of the SAR ADC at 32kS/s can be achieved with 0.42 mu W and 0.036 mm(2). The overall power of this microsystem is only 3.79mW for 256-channel neural sensing.
Design and Fabricate a Contact Lens Sensor with a Micro-Inductor Embedded for Intraocular Pressure Monitoring
(2012)
Tseng, Chien-Kai
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Huang, Yu-Chieh
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Tsai, Shang-Wei
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Yeh, Guan-Ting
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Chang, Chung-Hao
This paper presents a new type of micro-inductor sensor for intraocular pressure (IOP) measurement on soft contact lens substructure. The sensor was designed and fabricated by using MEMS fabrication technologies. The contact lens is for wearing on a cornea such that a curvature of the contact lens corresponds substantially to that of the cornea, and is preferably made of Hydroxyethylmethacrylate (HEMA) by cast-molding method of soft contact lens for high oxygen permeability and comfortable long-duration wearing. In this paper, we discuss a contact lens with micro-inductor measurement principle followed by a brief description of our sensor design and fabrication. Our first prototype without wireless has been tested in lab-simulation bench. We obtain a simulation and measurement results have good linearity between micro-inductor radius variation and oscillation frequency. In future work will be to optimize the fabrication technology and the design to reach a better resolution, also a radio frequency integrated circuit (RFIC) and antenna will be designed preferably embedded in the contact lens so that inductance value transfers to frequency value via LC oscillator circuit and transmits intraocular pressure sensing signal by wireless telemetry system.
Effects of Operating Temperature on Droplet Casting of Flexible Polymer/Multi-Walled Carbon Nanotube Composite Gas Sensors
(2017-01-01)
Chiou, Jin-Chern
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Wu, Chin-Cheng
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Huang, Yu-Chieh
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Chang, Shih-Cheng
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Lin, Tse-Mei
This study examined the performance of a flexible polymer/multi-walled carbon nanotube (MWCNT) composite sensor array as a function of operating temperature. The response magnitudes of a cost-effective flexible gas sensor array equipped with a heater were measured with respect to five different operating temperatures (room temperature, 40 degrees C, 50 degrees C, 60 degrees C, and 70 degrees C) via impedance spectrum measurement and sensing response experiments. The selected polymers that were droplet cast to coat a MWCNT conductive layer to form two-layer polymer/MWCNT composite sensing films included ethyl cellulose (EC), polyethylene oxide (PEO), and polyvinylpyrrolidone (PVP). Electrical characterization of impedance, sensing response magnitude, and scanning electron microscope (SEM) morphology of each type of polymer/MWCNT composite film was performed at different operating temperatures. With respect to ethanol, the response magnitude of the sensor decreased with increasing operating temperatures. The results indicated that the higher operating temperature could reduce the response and influence the sensitivity of the polymer/MWCNT gas sensor array. The morphology of polymer/MWCNT composite films revealed that there were changes in the porous film after volatile organic compound (VOC) testing.
Integration of Neural Sensing Microsystem with TSV-embedded Dissolvable mu-Needles Array, Biocompatible Flexible Interposer, and Neural Recording Circuits
(2016)
Huang, Yu-Chieh
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Hu, Yu-Chen
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Huang, Po-Tsang
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Wu, Shang-Lin
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You, Yan-Huei
Local brain connectivity is expected to lead to new models for neurological diseases, which may in turn result in advanced understanding and better treatment. This paper presents a neural sensing microsystem integrated with TSV-embedded dissolvable mu-needles array, ENIG bonding technology, biocompatible Au-TSV flexible interposer and neural recording circuits, for neural sensing implantation. An ultra-thin film bonding approach is proposed for integration of interposer assembly. Removing bonding wire by proposed bonding technology, the dimension of neural sensing system can be minimized to reduce surgical area and promote implant success rate. The signal quality of neural recording can be significantly improved by eliminating complex signal paths with 2.5D TSV integration from neural sensing interface to neural recording circuits.
Toward a Wirelessly Powered On-Lens Intraocular Pressure Monitoring System
(2016-09)
Chiou, Jin-Chern
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Hsu, Shun-Hsi
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Liao, Yu-Te
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Huang, Yu-Chieh
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Yeh, Guan-Ting
This paper presents a wireless on-lens intraocular pressure monitoring system, comprising a capacitance-to-digital converter and a wirelessly powered radio-frequency identification (RFID)-compatible communication system, for sensor control and data communication. The capacitive sensor was embedded on a soft contact lens of 200 mu m thickness using commercially available biocompatible lens material, to improve compliance and reduce user discomfort. The sensor chip was shown to achieve effective number of bits greater than 10 over a capacitance range up to 50 pF while consuming only 64-mu W power. The on-lens capacitive sensor could detect dielectric variation caused by changes in water content from a distance of 2 cm by using incident power from an RFID reader at 20 dBm. The maximum detectable distance was 11 cm with 30-dBm incident RF power. The rise in eye tissue temperature under 30-dBm RF exposure over an interval of 1 s was simulated and found to be less than 0.01 degrees C.
Toward a Wirelessly Powered On-Lens Intraocular Pressure Monitoring System
(2016-09-01)
Chiou, Jin-Chern
;
Hsu, Shun-Hsi
;
Liao, Yu-Te
;
Huang, Yu-Chieh
;
Yeh, Guan-Ting
This paper presents a wireless on-lens intraocular pressure monitoring system, comprising a capacitance-to-digital converter and a wirelessly powered radio-frequency identification (RFID)-compatible communication system, for sensor control and data communication. The capacitive sensor was embedded on a soft contact lens of 200 mu m thickness using commercially available biocompatible lens material, to improve compliance and reduce user discomfort. The sensor chip was shown to achieve effective number of bits greater than 10 over a capacitance range up to 50 pF while consuming only 64-mu W power. The on-lens capacitive sensor could detect dielectric variation caused by changes in water content from a distance of 2 cm by using incident power from an RFID reader at 20 dBm. The maximum detectable distance was 11 cm with 30-dBm incident RF power. The rise in eye tissue temperature under 30-dBm RF exposure over an interval of 1 s was simulated and found to be less than 0.01 degrees C.