Browsing by Author "Hwang, E."

Now showing 1 - 13 of 13

A Genetic Algorithm-based Method to Automatically Characterize and Classify Neurons.
(2012-01-01)
Hwang, E.
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Huang, H-L.
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Chao, C-Y.
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Kao, P-Y.
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Ke, C-C.
An optogenetic approach to examine the role of cytoplasmic Ran in acentrosomal microtubule nucleation in neurons.
(2018-12-15)
Lo, W.
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Hsu, C.
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Chiu, H.
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Hwang, E.
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生物科技學系
COLLAGEN VI PROTECTS AGAINST NEURONAL APOPTOSIS ELICITED BY ULTRAVIOLET IRRADIATION VIA AN AKT/PHOSPHATIDYLINOSITOL 3-KINASE SIGNALING PATHWAY
(2011-06-02)
Cheng, I. H.
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Lin, Y. -C.
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Hwang, E.
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Huang, H. -T.
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Chang, W. -H.
Collagen VI, one of the extracellular matrix proteins, has been implicated in regulating cell proliferation and reducing apoptosis in several different systems. However, the role of collagen VI in the central nervous system remains unclear. In this manuscript, we demonstrated that upon ultraviolet (UV) irradiation, mouse primary hippocampal neurons specifically up-regulate the expression of Col6a1, Col6a2, and Col6a3 mRNA and secreted collagen VI protein. Augmentation of collagen VI mRNA and protein after UV irradiation may have a neuroprotective role as suggested by the fact that extracellular supplying soluble collagen VI protein, but not other collagen proteins, reduced UV induced DNA damage, mitochondria dysfunction, and neurite shrinkage. We also tried to determine the signaling molecules that mediate the protective effect of collagen VI via Western blot and inhibitor analysis. After collagen VI treatment, UV irradiated neurons increased phosphorylation of Akt and decreased phosphorylation of JNK. Inhibiting Akt/Phosphatidylinositol 3-kinases (PI3K) pathway diminished the protective effect of collagen VI. Our study suggested a potential protective mechanism by which neurons up-regulate collagen VI production under stress conditions to activate Akt/PI3K anti-apoptotic signaling pathway. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
Cytoplasmic Ran regulates acentrosomal microtubule nucleation in neurons.
(2017-01-01)
Hsu, C.
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Chiu, H.
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Chen, W.
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Chen, Y.
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Huang, Y.
Examining the interaction of TPX2 and Importin-alpha isoforms in vitro and in vivo
(2015)
Hsieh, B.
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Liu, E.
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Hwang, E.
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生物科技學系
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生物資訊及系統生物研究所
Examining the interaction of TPX2 and Importin-alpha isoforms in vitro and in vivo
(2015)
Hsieh, B.
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Liu, E.
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Hwang, E.
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生物科技學系
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生物資訊及系統生物研究所
Microtubule and Protein Kinase A Interaction is Important for Neurite Morphogenesis
(2011)
Huang, Y-A.
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Tseng, D. T-H.
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Hwang, E.
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生物科技學系
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生物資訊及系統生物研究所
Nanoimprinted surface topology preferentially guides and enhances axon regeneration.
(2017-01-01)
Ho, T.
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Huang, Y.
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Lin, Y.
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Lee, C.
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Li, M.
Overexpressed Cep170 localizes as acentrosomal puncta along neurites and promotes neurite outgrowth.
(2018-12-15)
Goh, A.
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Huang, H.
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Hwang, E.
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生物科技學系
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生物資訊及系統生物研究所
Ran-dependent TPX2 activation promotes microtubule nucleation and neurite morphogenesis.
(2015)
Hwang, E.
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Chen, W.
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Chen, Y.
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Huang, Y.
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Kao, P.
Ran-dependent TPX2 activation promotes microtubule nucleation and neurite morphogenesis.
(2015)
Hwang, E.
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Chen, W.
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Chen, Y.
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Huang, Y.
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Kao, P.
Using Infra-Red Laser and Nanodiamond Coating to Perform Spot Axotomy.
(2015)
Lin, Y.
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Huang, H.
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Chao, H.
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Hsu, L.
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Hwang, E.
Using Infra-Red Laser and Nanodiamond Coating to Perform Spot Axotomy.
(2015)
Lin, Y.
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Huang, H.
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Chao, H.
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Hsu, L.
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Hwang, E.