Browsing by Author "Kan, LS"

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Guided three-dimensional molecular self-assembly on silicon substrates
(2006-06-26)
Chang, CC
;
Sun, KW
;
Kan, LS
;
Kuan, CH
;
生物科技學系
We demonstrate three-dimensional (3D) self-assemble growth of the metallothionein (Mn,Cd-MT-2) molecules on patterned semiconductor substrates. The MT molecules deposited on the patterned substrates were found to grow into 3D rod or ring-type nanostructures, depending on the shape of patterned nanostructures on the substrates. Dense arrays of 3D molecular nanorods or rings with an area density close to 10(10) cm(-2) were demonstrated with a pore size of 20 nm and a pitch size of 100 nm. Those engineered molecular nanostructures provide an excellent opportunity for biological applications, sensing sources of nanodevices, biochemical reactions on surfaces, and even single molecule studies. (c) 2006 American Institute of Physics.
Mn,Cd-metallothionein-2: A room temperature magnetic protean
(2006-02-24)
Chang, CC
;
Lee, SF
;
Sun, KW
;
Ho, CC
;
Chen, YT
Naturally occurring metallothionein (MT) is a metal binding protein, which binds to seven Zn2+ through 20 conserved cysteines and forms two metal binding clusters with a Zinc-Blende structure. We demonstrate that the MT, when substituting the Zn2+ ions by Mn2+ and Cd2+, exhibits magnetic hysteresis loop observable by SQUID from 10 to 330 K. The magnetic moment may have originated from the bridging effect of the sulfur atoms between the metal ions that leads to the alignment of the electron spins of the Mn2+ ions inside the clusters. The protein backbone may restrain the net spin moment of Mn2+ ions from thermal fluctuation. The modified magnetic-metallothionein is a novel approach to creating molecular magnets with operating temperatures up to 330 K. (c) 2005 Elsevier Inc. All rights reserved.
Protein folding: an antagonistic reaction of spontaneous folding and diffusion limited aggregation in nature
(2006-03-06)
Kan, LS
;
Chang, CC
;
生物科技學系
;
Department of Biological Science and Technology