Browsing by Author "Khan, IA"

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One pot synthesis of oxygenated tri-heterocycles as anti-microbial agents
(2005-11-01)
Khan, IA
;
Kulkarni, MV
;
Sun, CM
;
應用化學系
;
Department of Applied Chemistry
A one pot synthesis of an array of angularly linked tri-heterocycles with coumarin, benzofuran and furan rings is described. This high yielding synthesis is achieved by the reaction of various 4-bromomethylcoumarins with furyl o-hydroxyphenyl ketones involving benzylic nucleophilic displacement and intramolecular aldolization. All the compounds have been tested in vitro for their anti-microbial activity against Micrococcus aureus, Pseudomonas chinchori, Asperigillus fumigatus and Penicillium wortmanni at 100, 50, and 25 mu g ml(-1) concentrations. Chloro groups in the benzofuran ring enhanced the activity. (c) 2005 Elsevier SAS. All rights reserved.
Synthesis and biological evaluation of novel angularly fused polycyclic coumarins
(2005-08-01)
Khan, IA
;
Kulkarni, MV
;
Gopal, M
;
Shahabuddin, MS
;
Sun, CM
In a three-step sequence, an array of angularly fused polycyclic heterocycles with coumarin, benzofuran and pyridine rings were synthesized from 4-bromomethylcoumarins and salicylonitrile. All the final compounds were fully characterized and screened for anti-microbial, anti-inflammatory and analgesic activities. Several compounds exhibited promising inflammation inhibiting and anti-microbial properties. (c) 2005 Elsevier Ltd. All rights reserved.