Browsing by Author "Kishikawa, Yosuke"

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Photoredox-Catalyzed Hydrodifluoroalkylation of Alkenes Using Difluorohaloalkyl Compounds and a Hantzsch Ester
(2017-05-19)
Sumino, Shuhei
;
Uno, Misae
;
Fukuyarna, Takahide
;
Ryu, Ilhyong
;
Matsuura, Makoto
Photoredox-catalyzed hydrodifluoroalkylation of alkenes proceeded smoothly in the presence of a Hantzsch ester as a hydrogen source under visible light irradiation. The reaction was also applicable to the hydrodifluoroalkylation of alkynes, and a continuous photo flow reaction was also successful.
Synthesis of 4,4-Difluoroalkenes by Coupling of alpha-Substituted alpha,alpha-Difluoromethyl Halides with Allyl Sulfones under Photoredox Catalyzed Conditions
(2019-07-19)
Uno, Misae
;
Sumino, Shuhei
;
Fukuyama, Takahide
;
Matsuura, Makoto
;
Kuroki, Yoshichika
Photoredox-catalyzed allylation of alpha-gem-difluorinated organohalides with allyl sulfones proceeded smoothly under visible light irradiation to give 4,4-difluoroalkenes in good yields. In the presence of catalytic Ru(bpy)(3)Cl-2, Hantzsch ester, and diisopropylethylamine, the reaction was complete within 2 h. Using the same methodology, three-component cascade reactions to give 6,6-difluoroalkenes were carried out successfully.