Browsing by Author "Ko, Li-Wei"

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A Novel 16-Channel Wireless System for Electroencephalography Measurements With Dry Spring-Loaded Sensors
(2014-06-01)
Liao, Lun-De
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Wu, Shang-Lin
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Liou, Chang-Hong
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Lu, Shao-Wei
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Chen, Shi-An
Understanding brain function using electroencephalography (EEG) is an important issue for cerebral nervous system diseases, especially for epilepsy and Alzheimer\'s disease. Many EEG measurement systems are used reliably to study these diseases, but their bulky size and the use of wet sensors make them uncomfortable and inconvenient for users. To overcome the limitations of conventional EEG measurement systems, a wireless and wearable multichannel EEG measurement system is proposed in this paper. This system includes a wireless data acquisition device, dry spring-loaded sensors, and a size-adjustable soft cap. We compared the performance of the proposed system using dry versus conventional wet sensors. A significant positive correlation between readings from wet and dry sensors was achieved, thus demonstrating the performance of the system. Moreover, four different features of EEG signals (i.e., normal, eye-blinking, closed-eyes, and teeth-clenching signals) were measured by 16 dry sensors to ensure that they could be detected in real-life cognitive neuroscience applications. Thus, we have shown that it is possible to reliably measure EEG signals using the proposed system. This paper presents novel insights into the field of cognitive neuroscience, showing the possibility of studying brain function under real-life conditions.
A Simple Communication System based on Brain Computer Interface
(2015)
Singh, Avinash Kumar
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Wang, Yu-Kai
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King, Jun-Tai
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Lin, Chin-Teng
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Ko, Li-Wei
The current study presents one Brain Computer Interface (BCI) based communication system in which the intentional eye blink were extracted from the single channel EEG data. This system could be useful for the sufferers of motor disease, locked in syndrome, and paralysis. In particular, one new Human Computer Interface (HCI) can also benefit healthy users. To detect the intentional eye blinking in real-time, the score was calculated from delta, theta and gamma power band from the brain dynamics acquired from single channel through NeuroSky Headset wirelessly. The soft and hard blink represent \'0\' and \'1\' in this system respectively and formed four continuous bit string which map to the pre-defined text in this system. The mapped text was convert into speech and send to the speaker. The experimental results shows that this system can provide an accurate and convenient way to communicate through the brain dynamics.
A Vectorcardiogram-based Classification System for the Detection of Myocardial Infarction
(2011)
Huang, Chih-Sheng
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Ko, Li-Wei
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Lu, Shao-Wei
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Chen, Shi-An
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Lin, Chin-Teng
Myocardial infarction (MI), generally known as a heart attack, is one of the top leading causes of mortality in the world. In clinical diagnosis, cardiologists generally utilize 12-lead ECG system to classify patients into MI symptoms: 1. ST segment elevation, 2. ST segment depression or T wave inversion. However unstable ischemic syndromes have rapidly changing supply versus demand characteristics that is one of the several limitations of 12-lead ECG system for MI detection. In addition, the ECG sensor placements of 12-lead system is not easily donned and doffed for tele-healthcare monitoring at home. Vectorcardiogram (VCG) system in clinic is another type of diagnosis plot which represents the magnitude and direction of the electrical potential in the form of a vector loop during cardiac electric activity. The VCG system can easily acquire three ECG waves from X, Y, Z directions to composite vector signal in space and the VCG signals can be transferred to 12-lead ECG signal through Dower transformation and vice versa. Hence, this study attempts to develop a VCG-based classification system for the detection of Myocardial infarction. In the experiment results, the proposed system can select the proper ECG features based on cardiologist's knowledge and proposed principal moments of QRS complex. The classification performance of MI detection can be reached to 99.89% of sensitivity, 92.51% of specificity, 95.35% of positive predictive value, and 96.96% overall accuracy with maximum-likelihood classifier (MLC).
A Visual Attention Monitor Based on Steady-State Visual Evoked Potential
(2016-03)
Lee, Yi-Chieh
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Lin, Wen-Chieh
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Cherng, Fu-Yin
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Ko, Li-Wei
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生物科技學系
Attention detection is important for many applications. Automatic determination of users\' visual attention state is challenging because attention involves numerous complex and internal human cognitive functions. Behavioral observations, such as eye gaze or response to external stimuli, can provide clues for users\' visual attention state; however, users\' cognitive state cannot be easily known. Conventional electroencephalography-based methods detect attention by observing the dynamic changes in the frontal lobe of the brain, especially in the anterior cingulate cortex (ACC). However, that area in the brain is associated with many functions, some of which correlate with conscious experience but are not directly related to attention. In this paper, we design an attention monitoring system to detect whether the brain experiences a visual stimulus consciously. Our experiments verified the feasibility of our design, and the average classification rate ranged from 72% to 82%.
A Wireless Multifunctional SSVEP-Based Brain-Computer Interface Assistive System
(2019-09-01)
Lin, Chin-Teng
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Chiu, Ching-Yu
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Singh, Avinash Kumar
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King, Jung-Tai
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Ko, Li-Wei
Several kinds of brain-computer interface (BCI) systems have been proposed to compensate for the lack of medical technology for assisting patients who lose the ability to use motor functions to communicate with the outside world. However, most of the proposed systems are limited by their nonportability, impracticality, and inconvenience because of the adoption of wired or invasive electroencephalography acquisition devices. Another common limitation is the shortage of functions provided because of the difficulty of integrating multiple functions into one BCI system. In this paper, we propose a wireless, non-invasive and multifunctional assistive system which integrates steady state visually evoked potential-based BCI and a robotic arm to assist patients to feed themselves. Patients are able to control the robotic arm via the BCI to serve themselves food. Three other functions: 1) video entertainment; 2) video calling; and 3) active interaction are also integrated. This is achieved by designing a functional menu and integrating multiple subsystems. A refinement decision-making mechanism is incorporated to ensure the accuracy and applicability of the system. Fifteen participants were recruited to validate the usability and performance of the system. The averaged accuracy and information transfer rate achieved is 90.91% and 24.94 bit per min, respectively. The feedback from the participants demonstrates that this assistive system is able to significantly improve the quality of daily life.
Adaptive EEG-based alertness estimation system by using ICA-based fuzzy neural networks
(2006-11-01)
Lin, Chin-Teng
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Ko, Li-Wei
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Chung, I-Fang
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Huang, Teng-Yi
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Chen, Yu-Chieh
Drivers' fatigue has been implicated as a causal factor in many accidents. The development of human cognitive state monitoring system for the drivers to prevent accidents behind the steering wheel has become a major focus in the field of safety driving. It requires a technique that can continuously monitor and estimate the alertness level of drivers. The difficulties in developing such a system are lack of significant index for detecting drowsiness and the interference of, the complicated noise in a realistic and dynamic driving environment. An adaptive alertness estimation methodology based on electroencephalogram, power spectrum analysis, independent component analysis (ICA), and fuzzy neural network (FNNs) models is proposed in this paper or continuously monitoring driver's drowsiness level with concurrent changes in the alertness level. A novel adaptive feature selection mechanism is developed for automatically selecting effective frequency bands of ICA components for realizing an on-line alertness monitoring system based on the, correlation analysis between the time-frequency power spectra of ICA components and the driving errors defined as the deviation between the center of the vehicle and the cruising lane in the virtual-reality driving environment. The mechanism also provides effective and efficient features that can be fed into ICA-mixture-model-based self-constructing FNN to indirectly estimate driver's drowsiness level expressed by approximately and predicting the driving error.
Adaptive synchronization of chaotic systems with unknown parameters via new backstepping strategy
(2012-11-01)
Li, Shih-Yu
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Yang, Cheng-Hsiung
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Lin, Chin-Teng
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Ko, Li-Wei
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Chiu, Tien-Ting
In this paper, a new effective approach-backstepping with Ge-Yao-Chen (GYC) partial region stability theory (called BGYC in this article) is proposed to applied to adaptive synchronization. Backstepping design is a recursive procedure that combines the choice of a Lyapunov function with the design of a controller, and it presents a systematic procedure for selecting a proper controller in chaos synchronization. We further combine the systematic backstepping design and GYC partial region stability theory in this article, Lyapunov function can be chosen as a simple linear homogeneous function of states, and the controllers and the update laws of parameters shall be much simpler. Further, it also introduces less simulation error-the numerical simulation results show that the states errors and parametric errors approach to zero much more exactly and efficiently, which are compared with the original one. Two cases are presented in the simulation results to show the effectiveness and feasibility of our new strategy.
Alpha modulation in parietal and retrosplenial cortex correlates with navigation performance
(2012-01-01)
Chiu, Te-Cheng
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Gramann, Klaus
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Ko, Li-Wei
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Duann, Jeng-Ren
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Jung, Tzyy-Ping
The present study investigated the brain dynamics accompanying spatial navigation based on distinct reference frames. Participants preferentially using an allocentric or an egocentric reference frame navigated through virtual tunnels and reported their homing direction at the end of each trial based on their spatial representation of the passage. Task-related electroencephalographic (EEG) dynamics were analyzed based on independent component analysis (ICA) and subsequent clustering of independent components. Parietal alpha desynchronization during encoding of spatial information predicted homing performance for participants using an egocentric reference frame. In contrast, retrosplenial and occipital alpha desynchronization during retrieval covaried with homing performance of participants using an allocentric reference frame. These results support the assumption of distinct neural networks underlying the computation of distinct reference frames and reveal a direct relationship of alpha modulation in parietal and retrosplenial areas with encoding and retrieval of spatial information for homing behavior.
An EEG-based Classification System of Passenger's Motion Sickness Level by using Feature Extraction/Selection Technologies
(2010)
Yu, Yi-Hsin
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Lai, Pei-Chen
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Ko, Li-Wei
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Chuang, Chun-Hsiang
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Kuo, Bor-Chen
Past studies reported that the main electrogastrography (EEG) dynamic changes related to motion sickness (MS) were occurred in occipital, parietal, and somatosensory brain area, especially in the power increasing of the alpha band (8-13 Hz) and theta band (4-7 Hz) which had positive correlation with the subjective MS level. Depend on these main findings correlated with MS, we attempt to develop an EEG based classification system to automatically classify subject's MS level and find the suitable EEG features via common feature extraction, selection and classifiers technologies in this study. If we can find the regulations and then develop an algorithm to predict MS occurring, it would be a great benefit to construct a safe and comfortable environment for all drivers and passengers when they are cruising in the car, bus, ship or airplane. EEG is one of the best methods for monitoring the brain dynamics induced by motion-sickness because of its high temporal resolution and portability. After collecting the EEG signals and subjective MS level in a realistic driving environment, we first do the data pre-processing part including ICA, component clustering analysis and time-frequency analysis. Then we adopt three common feature extractions and two feature selections (FE/FS) technologies to extract or select the correlated features such as principal component analysis (PCA), linear discriminate analysis (LDA), nonparametric weighted feature extraction (NWFE), forward feature selections (FFS) and backward feature selections (BFS) and feed the feature maps into three classifiers (Gaussian Maximum Likelihood Classifier (ML), k-Nearest-Neighbor Classifier (kNN) and Support Vector Machine (SVM)). Experimental results show that classification performance of all our proposed technologies can be reached almost over 95%. It means it is possible to apply the effective technology combination to predict the subject's MS level in the real life applications. The better combination in this study is using LDA and Gaussian based ML classifier. This advantage can be widely used in machine learning area for developing the prediction algorithms in the future.
An EEG-based perceptual function integration network for application to drowsy driving
(2015-05-01)
Chuang, Chun-Hsiang
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Huang, Chih-Sheng
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Ko, Li-Wei
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Lin, Chin-Teng
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生物科技學系
Drowsy driving is among the most critical causes of fatal crashes. Thus, the development of an effective algorithm for detecting a driver\'s cognitive state demands immediate attention. For decades, studies have observed clear evidence using electroencephalography that the brain\'s rhythmic activities fluctuate from alertness to drowsiness. Recognition of this physiological signal is the major consideration of neural engineering for designing a feasible countermeasure. This study proposed a perceptual function integration system which used spectral features from multiple independent brain sources for application to recognize the driver\'s vigilance state. The analysis of brain spectral dynamics demonstrated physiological evidenced that the activities of the multiple cortical sources were highly related to the changes of the vigilance state. The system performances showed a robust and improved accuracy as much as 88% higher than any of results performed by a single-source approach. (C) 2015 Elsevier B.V. All rights reserved.
An EEG-based Subject- and Session-independent Drowsiness Detection
(2008-01-01)
Lin, Chin-Teng
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Pal, Nikhil R.
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Chuang, Chien-Yao
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Jung, Tzyy-Ping
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Ko, Li-Wei
Monitoring and predicting human cognitive state and performance using physiological signals such as Electroencephalogram (EEG) have recently gained increasing attention in the fields of brain-computer interface and cognitive neuroscience. Most previous psychophysiological studies of cognitive changes have attempted to use the same model for all subjects. However, the relatively large individual variability in EEG dynamics relating to loss of alertness suggests that for many operators, group statistics cannot be used to accurately predict changes in cognitive states. Attempts have also been made to build a subject-dependent model for each individual based on his/her pilot data to account for individual variability. However, such methods assume the cross-session variability in EEG dynamics to be negligible, which could be problematic due to electrode displacements, environmental noises, and skin-electrode impedance. Here first we show that the EEG power in the alpha and theta bands are strongly correlated with changes in the subject's cognitive state reflected through his driving performance and hence his departure from alertness. Then under very mild and realistic assumptions we derive a model for the alert state of the person using EEG power in the alpha and theta bands. We demonstrate that deviations (computed by Mahalanobis distance) of the EEG power in the alpha and theta bands from the corresponding alert models are correlated to the changes in the driving performance. Finally, for detection of drowsiness we use a linear combination of deviations of the EEG power in the alpha band and theta band from the respective alert models that best correlates with subject's changing level of alertness, indexed by subject's behavioral response in the driving task. This approach could lead to a practical system for noninvasive monitoring of the cognitive state of human operators in attention-critical settings.
An fMRI Study of Abrupt-Awake Episodes during Behavioral Microsleeps
(2011)
Chou, Yu-Hsiang
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Chuang, Chun-Chao
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Zao, John K.
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Ko, Li-Wei
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Lin, Chin-Teng
This paper reports the brain activation patterns of five subjects who were abruptly awakened from microsleeps in a simulated automotive driving experiment. By comparing the BOLD signals between behavioral microsleep (BM), abrupt awakening (AA) and post-abrupt awakening (post-AA) stages, we observed that visual area, frontal cortex, limbic lobe manifested more intense activation during the AA stage while frontal cortex, temporal cortex, primary motor area and insula were more activated during the post-AA stage. These results suggested that the subjects were likely in mental states differ from those associated with decision making processes as they went through and emerged from the abrupt awakening episodes.
An Intelligent Telecardiology System Using a Wearable and Wireless ECG to Detect Atrial Fibrillation
(2010-05-01)
Lin, Chin-Teng
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Chang, Kuan-Cheng
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Lin, Chun-Ling
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Chiang, Chia-Cheng
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Lu, Shao-Wei
This study presents a novel wireless, ambulatory, real-time, and autoalarm intelligent telecardiology system to improve healthcare for cardiovascular disease, which is one of the most prevalent and costly health problems in the world. This system consists of a lightweight and power-saving wireless ECG device equipped with a built-in automatic warning expert system. This device is connected to a mobile and ubiquitous real-time display platform. The acquired ECG signals are instantaneously transmitted to mobile devices, such as netbooks or mobile phones through Bluetooth, and then, processed by the expert system. An alert signal is sent to the remote database server, which can be accessed by an Internet browser, once an abnormal ECG is detected. The current version of the expert system can identify five types of abnormal cardiac rhythms in real-time, including sinus tachycardia, sinus bradycardia, wide QRS complex, atrial fibrillation (AF), and cardiac asystole, which is very important for both the subjects who are being monitored and the healthcare personnel tracking cardiac-rhythm disorders. The proposed system also activates an emergency medical alarm system when problems occur. Clinical testing reveals that the proposed system is approximately 94% accurate, with high sensitivity, specificity, and positive prediction rates for ten normal subjects and 20 AF patients. We believe that in the future a business-card-like ECG device, accompanied with a mobile phone, can make universal cardiac protection service possible.
Applying the Fuzzy C-means based Dimension Reduction to Improve the Sleep Classification System
(2013)
Huang, Chih-Sheng
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Lin, Chun-Ling
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Yang, Wen-Yu
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Ko, Li-Wei
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Liu, Sheng-Yi
Having a well sleep quality is important factor in our daily life. The evaluation of sleep stages has become an important issue due to the distribution of sleep stages across a whole night relates to sleep quality. This study aims to propose a sleep classification system, consists of a preliminary wake detection rule, sleep feature extraction, fuzzy c-means based dimension reduction, support vector machine with radial basis function kernel, and adaptive adjustment scheme, with only FP1 and FP2 electroencephalography. Compared with the results from the sleep technologist, the average accuracy and Kappa coefficient of the proposed sleep classification system is 70.92% and 0.6130, respectively, for individual 10 normal subjects. Thus, the proposed sleep classification system could provide a preliminary report of sleep stages to assistant doctors to make decision if a patient needs to have a detailed testing in a sleep laboratory.
Arousing Feedback Rectifies Lapse in Performance and Corresponding EEG Power Spectrum
(2010)
Jung, Tzyy-Ping
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Huang, Kuan-Chih
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Chuang, Chun-Hsiang
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Chen, Jian-Ann
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Ko, Li-Wei
This study explores electroencephalographic (EEG) dynamics and behavioral changes in response to arousing auditory signals presented to individuals experiencing momentary cognitive lapses. Arousing auditory feedback was delivered to the subjects in half of the non-responded lane-deviation events during a sustained-attention driving task, which immediately agitated subject\'s responses to the events. The improved behavioral performance was accompanied by concurrent power suppression in the theta- and alpha-bands in the lateral occipital cortices. This study further explores the feasibility of estimating the efficacy of arousing feedback presented to the drowsy subjects by monitoring the changes in EEG power spectra.
ASSESSING EFFECTIVENESS OF VARIOUS AUDITORY WARNING SIGNALS IN MAINTAINING DRIVERS' ATTENTION IN VIRTUAL REALITY-BASED DRIVING ENVIRONMENTS
(2009-06-01)
Lin, Chin-Teng
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Chiu, Tien-Ting
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Huang, Teng-Yi
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Chao, Chih-Feng
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Liang, Wen-Chieh
Drivers' fatigue contributes to traffic accidents, so drivers must maintain adequate alertness. The effectiveness of audio alarms in maintaining driving performance and characteristics of alarms was studied in a virtural reality-based driving environment. Response time to the car's drifting was measured under seven conditions: with no warnings and with continuous warning tones (500 Hz, 1750 Hz, and 3000 Hz), and with tone bursts at 500 Hz, 1750 Hz, and 3000 Hz. Analyses showed the audio warning signals significantly improved driving. Further, the tones' spectral characteristics significantly influenced the effectiveness of the warning.
Assessment of Musical Training Induced Neuroplasticity by Auditory Event Related Potentials and Neural Networks
(2009)
Liang, Sheng-Fu
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Liu, Chi-Sheng
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Chang, Wan-Lin
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Tsao, Yu-Hsiang
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Ko, Li-Wei
Music provides a tool to study numerous aspects of neuroscience from motion-skill to emotion since listening to and producing music involves many brain functions. The musician\'s brain is also regarded as an ideal model to investigate plasticity of the human brain. In this paper, an EEG-based neural network is proposed to assess neuroplasticity induced by musical training. A musical chord perception experiment is designed to acquire and compare the behavioral and neural responses of musicians and non-musicians. The ERPs elicited by the consonant and dissonant chords are combined together as the features of the model. The principle component analysis (PCA) is used to reduce feature dimensions and the dimension-reduced features are input to a feedforward neural network to recognize the brain potentials belong to a musician or a non-musician. The accuracy can reach 97% in average for leave-one-out cross validation of six subjects in this experiment. It demonstrates the feasibility of assessing effects of musical training by ERP signals elicited by musical chord perception.
Associations Among Emotional State, Sleep Quality, and Resting-State EEG Spectra: A Longitudinal Study in Graduate Students
(2020-04-01)
Komarov, Oleksii
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Ko, Li-Wei
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Jung, Tzyy-Ping
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交大名義發表
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生物資訊及系統生物研究所
University students are routinely influenced by a variety of natural stressors and experience irregular sleep-wake cycles caused by the necessity to trade sleep for studying while dealing with academic assignments. Often these factors result in long-term issues with daytime sleepiness, emotional instability, and mental exhaustion, which may lead to difficulties in the educational process. This study introduces the Daily Sampling System (DSS) implemented as a smartphone application, which combines a set of self-assessment scales for evaluating variations in the emotional state and sleep quality throughout a full academic term. In addition to submitting the daily sampling scores, the participants regularly filled in the Depression, Anxiety, and Stress Scales (DASS) reports and took part in resting-state EEG data recording immediately after report completion. In total, this study collected 1835 daily samples and 94 combined DASS with EEG datasets from 18 university students (aged 23-27 years), with 79.3 +/- 15.3% response ratio in submitting the daily reports during an academic semester. The results of pairwise testing and multiple regression analysis demonstrate that the daily level of self-perceived fatigue correlates positively with stress, daytime sleepiness, and negatively with alertness on awakening, self-evaluated sleep quality, and sleep duration. The spectral analysis of the EEG data reveals a significant increase in the resting-state spectral power density across the theta and low-alpha frequency bands associated with increased levels of anxiety and stress. Additionally, the state of depression was accompanied by an intensification of high-frequency EEG activity over the temporal regions. No significant differences in prefrontal alpha power asymmetry were observed under the described experimental conditions while comparing the states of calmness and emotional arousal of the participants for the three conditions of depression, anxiety, and stress.
Automatic Design for Independent Component Analysis based Brain-computer Interfacing
(2013)
Chuang, Chun-Hsiang
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Lin, Yuan-Pin
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Ko, Li-Wei
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Jung, Tzyy-Ping
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Lin, Chin-Teng
This study proposes a new framework, independent component ensemble, to leverage the acquired knowledge into a truly automatic and on-line EEG-based brain-computer interfacing (BCI). The envisioned design includes: (1) independent source recover using independent component analysis (ICA) (2) automatic selection of the independent components of interest (ICi) associated with human behaviors; (3) multiple classifiers with a parallel constructing and processing structure; and (4) a simple fusion scheme to combine the decisions from multiple classifiers. Its implications in BCI are demonstrated through a sample application: cognitive-state monitoring of participants performing a realistic sustained-attention driving task. Empirical results showed the proposed ensemble design could provide an improvement of 7%similar to 15% in overall accuracy for the classification of the arousal state and the driving performance. In summary, constructing ICi-ensemble classifiers and combining their outputs demonstrates a practical option for ICA-based BCIs to reduce the risk of not obtaining any desired independent source or selecting an inadequate component. Most importantly, the ensemble design for integrating information across multiple brain areas creates potentials for developing more complicated BCIs for real world applications.
Automatic Identification of Useful Independent Components with a View to Removing Artifacts from EEG Signal
(2009)
Huang, Hwa-Shan
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Pal, Nikhil R.
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Ko, Li-Wei
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Lin, Chin-Teng
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電控工程研究所
Removal of artifacts is an important step in any research in /application of electroencephalogram (EEG). The artifacts may contain eye-blinking, muscle noise, heart signal, line noise, and environmental effect. Such noises often make the raw EEG signals not very useful for extraction/identification of physiological phenomena from EEG. The independent component analysis (ICA) is a popular technique for artifact removal in brain research and some reports demonstrate that ICA can remove the artifacts with lower (acceptable) loss of information. But, these reports select useful independent components manually, primarily by looking at the scalp-plots. This is of great inconvenience and is a barrier for BCI or real-time applications of EEG. In this paper, we demonstrate that machine learning methods could be quite effective to discriminate useful independent components from artifacts and our findings suggests the possibility of developing a 'universal" machine for artifact removal in EEG.