Browsing by Author "Kosheleva, Olga"

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Investigation of nanoparticle-assisted ultrasound therapy for treating implanted breast tumors in mice
(2017-01-01)
Kosheleva, Olga
;
Lai, Tsung-Ching
;
Chan, Yung-Chieh
;
Hsiao, Michael
;
Ng, Shok-Li
The presence of nanoparticles within an ultrasonic field has been previously shown to cause ultrasound to preferentially destroy cancerous cells over corresponding normal cells. Such treatment, termed nanoparticle-assisted ultrasound therapy (NAUT), has now been applied to subcutaneously implanted tumors in mice. Xenografted tumors were exposed to therapeutic ultrasound, with and without intratumoral injections of nanoparticles over a period of 4 weeks. Post-treatment, tumors that received nanoparticle injections were found to be substantially smaller than controls, suggesting that nanoparticle presence significantly increases the efficacy of ultrasonic treatment of solid tumors.