Browsing by Author "Lai, Yen-Hsun"

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Application of 2-Azido-2-deoxythioglycosides for beta-Glycoside Formation and Oligosaccharide Synthesis
(2012-05-01)
Mong, Kwok-Kong Tony
;
Yen, Yu-Fang
;
Hung, Wei-Cheng
;
Lai, Yen-Hsun
;
Chen, Jiun-Han
Most natural 2-acetamido-2-deoxyglycosides exist in a 1,2-trans-beta-glycosidic configuration. This study investigated the use of 2-azido-2-deoxythioglycosides for 1,2-trans-beta-glycosidic bond formation under low-concentration glycosylation conditions. Further application of the 2-azido-2-deoxythioglycosyl substrates for one-pot oligosaccharide synthesis was demonstrated in the synthesis of protected beta-(1?6)-N-acetylglucosamine trimer, core-6serine conjugate, and F1a serine conjugate.
Dimethylformamide: An Unusual Glycosylation Modulator
(2011)
Lu, Shao-Ru
;
Lai, Yen-Hsun
;
Chen, Jiun-Han
;
Liu, Chih-Yueh
;
Mong, Kwok-Kong Tony
Total Synthesis of a Glycoglycerolipid from Meiothermus taiwanensis through a One-Pot Glycosylation Reaction and Exploration of its Immunological Properties
(2013-12-01)
Ghosh, Bhaswati
;
Lai, Yen-Hsun
;
Shih, Yu-Yin
;
Pradhan, Tapan Kumar
;
Lin, Chun-Hung
The total synthesis of a glycoglycerolipid isolate of Meiothermus taiwanensis and its truncated structural analogues is reported. Our synthesis employed DMF-modulated and low-concentration glycosylation reactions for the construction of - and -glycosidic bonds in the absence of participating protecting groups. Further simplification of the synthesis was achieved by employing a low-concentration one-pot glycosylation procedure. Preliminary immunological studies showed that one of the truncated structural analogues suppressed the cytokine production of THP-1 monocytes.