Browsing by Author "Lee, Cheng-Yen"

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A 98.6 mu W Acoustic Signal Processor for Fully-Implantable Cochlear Implants
(2016)
Liu, Hao-Min
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Lin, Yung-Jen
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Lee, Yu-Chi
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Lee, Cheng-Yen
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Yang, Chia-Hsiang
This paper presents a low-power acoustic signal processor for fully-implantable cochlear implants. The developed processor supports adaptive beamforming, frequency-domain analysis, envelope detection, channel combination, and magnitude compression. Power and area are minimized by leveraging dedicated real-valued FFT, register count minimization, data allocation optimization, hardware complexity reduction, and minimum-energy-point operation. Compared to complexvalued FFT, real-valued FFT achieves 44.36% power reduction. Register count minimization and data allocation for FFT output reordering yields 28.07% and 27.09% area and power reduction, respectively. Envelope detection and log-compression are realized by hardware-efficient CORDIC engines. The processor is scalable to support various numbers of channels. This chip is implemented in 90-nm CMOS and the core area is 0.47 mm(2). It dissipates 98.6 mu W at 50 kHz, 0.33 V for a latency of 3 ms.
A Digital-Type GaN Driver with Current-Pulse-Balancer Technique Achieving Sub-Nanosecond Current Pulse Width for High-Resolution and Dynamic Effective Range LiDAR System
(2019-01-01)
Ma, Yu-Sheng
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Lin, Zong-Yi
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Lin, Yen-Ting
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Lee, Cheng-Yen
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Huang, Tzu-Ping
A High Current efficiency Stacked Digital Low Dropout Array with True-Random-Noise Injection and Ultralow Output Ripple for Power-Side Channel Attack Protection
(2019-01-01)
Lee, Cheng-Yen
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Huang, Tzu-Ping
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Chen, Ke-Horng
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Lin, Ying-Hsi
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Lin, Shian-Ru
This paper proposes a stacked digital low dropout (DLDO) array with three stacked groups to improve security and efficiency, consuming 1/3 of the input current in the prior art. The security is improved by two mechanisms. The advanced encryption standard (AES) engine can be one of point of loads (POLs) hidden in the deeper levels to minimize the disturbance from the AES to the input current. The other is the digital balanced interleave control (DBIC) receives random sources from internal leakage current frequency generator (LCFG) to generate randomly noise current to further hide the current interference caused by the AFS. Due to DBIC anti LCFG techniques, the correlation between input current and AES current is low to 0.006, which is 150 times lower than that of conventional DLDO.
A Standard-Cell-Design-Flow Compatible Energy-Recycling Logic With 70% Energy Saving
(2016-01)
Lee, Cheng-Yen
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Hsieh, Ping-Hsuan
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Yang, Chia-Hsiang
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電子工程學系及電子研究所
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Department of Electronics Engineering and Institute of Electronics
This paper presents an energy-recycling micro-architecture and the associated adiabatic logic for ultra-low energy applications, such as implantable bioelectronics. The proposed design achieves low power by transferring and recycling energy between digital logic blocks along with the signal propagation. The CMOS-like layout methodology allows the adiabatic logic core to be synthesized and auto-placed-and-routed with current EDA tools for complex digital systems. A 50% energy saving can be achieved for up to 100 MHz compared to conventional static CMOS logic. As a proof of concept, a 14-tap 8-bit finite impulse response (FIR) filter has been implemented in 90-nm CMOS for implantable neural signal processing. With only 16% area overhead compared to the static CMOS counterpart, the proposed design achieves 70% to 53% of energy reduction for 87 kHz to 410 kHz from a 1 V supply. The FIR filter realized with the proposed energy-recycling logic achieves an FoM of 5.33 nW/MHz/Tap/In-bit/Coeff-bit, yielding a 1.9x to 42x higher energy efficiency than the state-of-the-art custom energy-efficient FIR designs.
Double autophagy modulators reduce 2-deoxyglucose uptake in sarcoma patients
(2015-10-06)
Chi, Mau-Shin
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Lee, Cheng-Yen
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Huang, Su-Chen
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Yang, Kai-Lin
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Ko, Hui-Ling
Rationale: According to the metabolic symbiosis model, cancer stromal fibroblasts could be hijacked by surrounding cancer cells into a state of autophagy with aerobic glycolysis to help provide recycled nutrients. The purpose of this study was to investigate whether combined treatment with the autophagy inhibitor: hydroxychloroquine (HCQ) and the autophagy inducer: sirolimus (rapamycin, Rapa) would reduce glucose utilization in sarcoma patients. Methods: Ten sarcoma patients who failed first-line treatment were enrolled in this study. They were treated with 1 mg of Rapa and 200 mg of HCQ twice daily for two weeks. The standardized uptake values (SUV) from pretreatment and posttreatment [F-18]-fluorodeoxyglucose positron emission tomography (FDG PET) scans were reviewed, and changes from the baseline SUVmax were evaluated. Results: Based on FDG PET response criteria, six patients had a partial response; three had stable disease, and one had progressive disease. Nevertheless, none of them showed a reduction in tumor volume. The mean SUVmax reduction in the 34 lesions evaluated was -19.6% (95% CI = -30.1% to -9.1%), while the mean volume change was +16.4% (95% CI = +5.8% to + 27%). Only grade 1 toxicities were observed. Elevated serum levels of lactate dehydrogenase were detected after treatment in most metabolic responders. Conclusions: The results of reduced SUVmax without tumor volume reduction after two weeks of Rapa and HCQ treatment may indicate that non-proliferative glycolysis occurred mainly in the cancer associated fibroblast compartment, and decreased glycolytic activity was evident from Rapa + HCQ double autophagy modulator treatment.