Browsing by Author "Lee, Pin-Shiuan"

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Assessment of Quantitative Magnetoencephalography using Cross-frequency Phase-phase Coupling
(2018-01-01)
Lee, Pin-Shiuan
;
Chen, Yong-Sheng
;
Chan, Hui-Ling
;
Chen, Li-Fen
;
資訊工程學系
Cross-frequency phase-phase coupling (n:m CFC) within a cortical region has been proposed as a potential mechanism to regulate neural communication between different temporal scales. This study investigated n:m CFC values between high and low frequencies in resting-state networks using magnetoencephalographic (MEG) data. Simulation experiments with different frequency pairs were first conducted to evaluate the effect of SNR on the estimation of phase and CFC. The values of n:m CFC between each pair of delta, theta, alpha, beta, and gamma frequencies were estimated from eye-open resting-state MEG data. The topographic maps of CFC values between alpha and other frequencies were illustrated. The results of simulation data showed the increased accuracy of phase and n:m CFC estimation for balanced power of two targeted frequencies. Results of MEG data exhibited that CFC maps of low-alpha activity presented broadly distributed coupling with high frequencies (including beta and gamma) in the frontal regions of salient ventral attention and frontoparietal control networks, whereas high-alpha activity coupling with the gamma band in the posterior part of frontoparietal control network. Our study demonstrates the versatile of n:m CFC values at rest in human brain. Caution should be considered when n:m CFC values would be used as an index of dysfunction at resting state in diseased brains.
Distinct neuronal oscillatory responses between patients with bipolar and unipolar disorders: A magnetoencephalographic study
(2010-06-01)
Lee, Pin-Shiuan
;
Chen, Yong-Sheng
;
Hsieh, Jen-Chuen
;
Su, Tung-Ping
;
Chen, Li-Fen
Background: Bipolar disorder (BD) and major depressive disorder (MDD) have distinct pathophysiologies but similar depressive appearances. The present study aimed at the differentiation of the brain responses between BD and MDD patients. We hypothesized that different affective disorder patients may have distinct patterns of oscillatory cortical activities in response to negative emotional stimuli. Methods: Twenty BD patients, twenty MDD patients, and twenty age- and gender-matched healthy normal subjects were recruited. We adopted an implicit emotional task with facial image stimuli. The acquired event-related magnetoencephalographic signals were processed by the time-frequency analysis and beamformer-based source imaging techniques followed by statistical inference. Results: We found that there were gamma oscillation decreases in the frontal regions of both BD and MOD patients, gamma oscillation increases in the bilateral temporal regions of MDD, and alpha-beta rhythm increases in BD patients. Relative to the cortical activation in the control group, the BD patients displayed more widely increased oscillatory activities over the fronto-parieto-occipital regions than MOD patients. Conclusions: Our results demonstrate the distinct neuropathological patterns of emotional responses in BD and MDD patients. The findings suggest that the dysfunction of emotion regulation in BD may result from the increased sensitivity to emotionally salient information, implicating the potential cause of the emotion lability. The present study also suggests that the implicit emotional task is an effective approach to differentiate bipolar from unipolar disorders and their distinct neuropathological patterns to emotional stimuli may provide objective and quantitative measures for potential diagnostic significance. (C) 2009 Elsevier BM. All rights reserved.
Encoding of menstrual pain experience with theta oscillations in women with primary dysmenorrhea
(2017-11-22)
Lee, Pin-Shiuan
;
Low, Intan
;
Chen, Yong-Sheng
;
Tu, Cheng-Hao
;
Chao, Hsiang-Tai
Theta oscillation (4-7 Hz) is well documented for its association with neural processes of memory. Pronounced increase of theta activity is commonly observed in patients with chronic neurogenic pain. However, its association with encoding of pain experience in patients with chronic pain is still unclear. The goal of the present study is to investigate the theta encoding of sensory and emotional information of long-term menstrual pain in women with primary dysmenorrhea (PDM). Forty-six young women with PDM and 46 age-matched control subjects underwent resting-state magnetoencephalography study during menstrual and periovulatory phases. Our results revealed increased theta activity in brain regions of pain processing in women with PDM, including the right parahippocampal gyrus, right posterior insula, and left anterior/middle cingulate gyrus during the menstrual phase and the left anterior insula and the left middle/inferior temporal gyrus during the periovulatory phase. The correlations between theta activity and the psychological measures pertaining to pain experience (depression, state anxiety, and pain rating index) implicate the role of theta oscillations in emotional and sensory processing of pain. The present study provides evidence for the role of theta oscillations in encoding the immediate and sustained effects of pain experience in young women with PDM.