Browsing by Author "Lee, TY"

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An agent-based system to discover protein-protein interactions, identify protein complexes and proteins with multiple peptide mass fingerprints
(2006-07-15)
Lee, TY
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Horng, JT
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Juan, HF
;
Huang, HD
;
Wu, LC
Proteins "work together" by actually binding to form multicomponent complexes that carry out specific functions. Proteomic analyses based on the mass spectrum are now key methods to determine the components in protein complexes. The protein-protein interaction or functional association may be known to exist among the extracted protein spots while analyzing the proteins on the 2D gel. In this study, we develop an agent-based system, namely AgentMultiProtIdent, which integrated two protein identification tools and a variety of databases storing relations among proteins and used to discover protein-protein interactions and protein functional associations, and identify protein complexes and proteins with multiple peptide mass fingerprints as input. The system takes Multiple Peptide Mass Fingerprints (PMFs) as a whole in the protein complex or protein identification. With the relations among proteins, it may greatly improve the accuracy of identification of protein complexes. Also, possible relationship of the multiple peptide mass fingerprints, such as ontology relation, can be discovered by our system, especially in the identification of protein complexes.
Design of a voice coil motor used in the focusing system of a digital video camera
(2005-10-01)
Yu, HC
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Lee, TY
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Wang, SJ
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Lai, ML
;
Ju, JJ
This paper raises a valid method to design a voice coil motor (VCM) used in the focusing system of a digital video camera (DVC). A better VCM performance, such as lower battery consumption, higher efficiency, and shorter focusing time, can be achieved by turning the diameter of a winding coil, the thickness of the magnet, and the winding spaces in a VCM.
Distance-spectrum formulas on the largest minimum distance of block codes
(2000-05-01)
Chen, PN
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Lee, TY
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Han, YS
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電信工程研究所
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Institute of Communications Engineering
A general formula for the asymptotic largest minimum distance (in block length) of deterministic block codes under generalized distance functions (not necessarily additive, symmetric, and bounded) is presented. As revealed in the formula, the largest minimum distance can be fully determined by the ultimate statistical characteristics of the normalized distance function evaluated under a properly chosen random-code generating distribution. Interestingly, the new formula has an analogous form to the general information-spectrum expressions of the channel capacity and the optimistic channel capacity, respectively derived by Verdu-Han [29] and Chen-Alajaji [7], [8], As a result, a minor class of distance functions for which the largest minimum distance can be derived is characterized. A general Varshamov-Gilbert lower bound is next addressed. Some discussions on the tightness of the general Varshamov-Gilbert bound are also provided. Finally, lower bounds on the largest minimum distances for several specific block coding schemes are rederived in terms of the new formulas, followed by comparisons with the known results devoted to the same codes.
Electrooptical properties of an aligned phase-change guest-host mode liquid crystal display
(1998-12-01)
Wu, JJ
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Lee, TY
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Chen, SH
;
Kuo, CL
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光電工程學系
We have studied the electrooptical properties of an aligned phase-change guest-host (PCGH) mode liquid crystal display. Samples with various thickness-to-natural pitch ratios d/p(0) are fabricated. For each d/p(0), we measure the phase transition fields, the ON- and OFF-state transmittances and the response times. The phase transition fields are compared to the numerical values calculated from theory, In addition, it is found that when d/p(0) greater than or equal to 1.2 the d/p(0) ratio hardly affects the transmittances but does affect the response times of the sample film. The experimental result also demonstrates that the response times and the phase transition voltages are affected by the rubbing condition.
Electrooptical properties of an aligned phase-change guest-host mode liquid crystal display
(1998-12-01)
Wu, JJ
;
Lee, TY
;
Chen, SH
;
Kuo, CL
;
光電工程研究所
We have studied the electrooptical properties of an aligned phase-change guest-host (PCGH) mode liquid crystal display. Samples with various thickness-to-natural pitch ratios d/p(0) are fabricated. For each d/p(0), we measure the phase transition fields, the ON- and OFF-state transmittances and the response times. The phase transition fields are compared to the numerical values calculated from theory, In addition, it is found that when d/p(0) greater than or equal to 1.2 the d/p(0) ratio hardly affects the transmittances but does affect the response times of the sample film. The experimental result also demonstrates that the response times and the phase transition voltages are affected by the rubbing condition.
Electrooptical properties of an aligned phase-change guest-host mode liquid crystal display (vol 37, pg 6506, 1998)
(1999-08-01)
Wu, JJ
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Lee, TY
;
Chen, SH
;
Kuo, CL
;
光電工程學系
Incorporating hidden Markov models for identifying protein kinase-specific phosphorylation sites
(2005-07-30)
Huang, HD
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Lee, TY
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Tzeng, SW
;
Wu, LC
;
Horng, JT
Protein phosphorylation, which is an important mechanism in posttranslational modification, affects essential cellular processes such as metabolism, cell signaling, differentiation, and membrane transportation. Proteins are phosphorylated by a variety of protein kinases. In this investigation, we develop a novel tool to computationally predict catalytic kinase-specific phosphorylation sites. The known phosphorylation sites from public domain data sources are categorized by their annotated protein kinases. Based on the concepts of profile Hidden Markov Models (HMM), computational models are trained from the kinase-specific groups of phosphorylation sites. After evaluating the trained models, we select the model with highest accuracy in each kinase-specific group and provide a Web-based prediction tool for identifying protein phosphorylation sites. The main contribution here is that we have developed a kinase-specific phosphorylation site prediction tool with both high sensitivity and specificity. (c) 2005 Wiley Periodicals, Inc.
KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites
(2005-07-01)
Huang, HD
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Lee, TY
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Tzeng, SW
;
Horng, JT
;
生物資訊及系統生物研究所
KinasePhos is a novel web server for computationally identifying catalytic kinase-specific phosphorylation sites. The known phosphorylation sites from public domain data sources are categorized by their annotated protein kinases. Based on the profile hidden Markov model, computational models are learned from the kinase-specific groups of the phosphorylation sites. After evaluating the learned models, the model with highest accuracy was selected from each kinase-specific group, for use in a web-based prediction tool for identifying protein phosphorylation sites. Therefore, this work developed a kinase-specific phosphorylation site prediction tool with both high sensitivity and specificity. The prediction tool is freely available at http://KinasePhos.mbc. nctu.edu.tw/.
Low power consumption focusing actuator for a mini video camera
(2006-04-15)
Yu, HC
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Lee, TY
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Lin, SK
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Kuo, LT
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Wang, SJ
A novel low power consumption autofocusing actuator in a mini video camera is constructed in accordance with the result of a systematic design procedure of voice coil motors (VCM). This paper emphasizes the position control of such a VCM. The position feedback signals are provided by a magnetoresistive (MR) encoder. The position estimation algorithm (PEA) is developed to precisely decode the MR signals for the position of the moving part of the VCM. Different postures change the loading of the moving part of the VCM, so that an adaptive model-following control system based on the PEA is proposed to compensate for the loading variation. The experiments verify the fast dynamic performance and high power efficiency of the VCM. (C) 2006 American Institute of Physics.
MultiProtident: Identifying proteins using database search and protein-protein interactions
(2005-05-01)
Huang, HD
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Lee, TY
;
Wu, LC
;
Lin, FM
;
Juan, HF
Protein identification is important in proteomics. Proteomic analyses based on mass spectra (MS) constitute innovative ways to identify the components of protein complexes. Instruments can obtain the mass spectrum to an accuracy of 0.01 Da or better, but identification errors are inevitable. This study shows a novel tool, MultiProtldent, which can identify proteins using additional information about protein-protein interactions and protein functional associations. Both single and multiple Peptide Mass Fingerprints (PMFs) are input to MultiProtldent, which matches the PMFs to a theoretical peptide mass database. The relationships or interactions among proteins are considered to reduce false positives in PMF matching. Experiments to identify protein complexes reveal that MultiProtldent is highly promising. The website associated with this study is http://dbms104.csie.ncu.edu.tw/.
Phase transition voltage and response time of an aligned phase-change-guest-host mode of liquid-crystal film
(1998-11-23)
Wu, JJ
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Lee, TY
;
Chen, SH
;
Kuo, CL
;
光電工程學系
We have studied the electro-optical properties of the aligned phase-change-guest-host (PCGH) mode liquid-crystal display. The PCGH material is spread between two glass substrates. Each substrate has previously been coated with a homeotropic alignment layer and has been softly rubbed. Samples with various thickness-to-natural pitch ratio d/p(0) are fabricated. It is found that, in some ranges of the d/p(0) ratio, the response times and phase transition voltage are affected by the rubbing direction. (C) 1998 American Institute of Physics. [S0003-6951(98)04546-X].
Trading CDPD availability and voice blocking probability in cellular networks
(1998-03-01)
Chuang, YM
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Lee, TY
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Lin, YB
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資訊工程學系
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Department of Computer Science
Cellular digital packet data offers mobile users access to a low-cost, ubiquitous, wireless data network. CDPD can be overlaid on existing AMPS analog cellular systems and share their infrastructure equipment on a noninterfering basis.Since CDPD utilizes the idle radio resources of AMPS, it is important to ensure that the normal AMPS activities are not affected by CDPD. Several timers and system parameters are defined in CDPD for this purpose. This article investigates how these timers and parameters affect the performance of AMPS/CDPD systems. Our study provides guidelines for the selection of input parameters to aid CDPD network planning. Specifically, we study the trade-off between CDPD availability and voice blocking probability. In this article, CDPD availability is defined as the proportion of time that the RF channels can be used to transmit CDPD data. We observe that selecting too large values for CDPD dwell time and the maximum number of CDPD channel streams will degrade the voice blocking probability without improving CDPD availability. On the other hand, selecting a too large value for the CDPD layoff time will degrade CDPD availability without improving voice blocking probability.