Browsing by Author "Lee, Tai-Hua"

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One pot synthesis of bioactive benzopyranones through palladium-catalyzed C-H activation and CO insertion into 2-arylphenols
(2013)
Lee, Tai-Hua
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Jayakumar, Jayachandran
;
Cheng, Chien-Hong
;
Chuang, Shih-Ching
;
應用化學系
Palladium-catalyzed oxidative carbonylation of 2-arylphenols through C-H bond activation and C-C and C-O bond formation under acid-base free and mild conditions has been developed. The reaction tolerates a variety of substrates and provides biologically important benzopyranone derivatives in up to 87% isolated yield.
One-Pot Synthesis of Highly Substituted Polyheteroaromatic Compounds by Rhodium(III)-Catalyzed Multiple C-H Activation and Annulation
(2014-09-08)
Jayakumar, Jayachandran
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Parthasarathy, Kanniyappan
;
Chen, Yi-Hsiang
;
Lee, Tai-Hua
;
Chuang, Shih-Ching
A new method for the synthesis of highly substituted naphthyridine-based polyheteroaromatic compounds in high yields proceeds through rhodium(III)-catalyzed multiple CH bond cleavage and CC and CN bond formation in a one-pot process. Such highly substituted polyheteroaromatic compounds have attracted much attention because of their unique -conjugation, which make them suitable materials for organic semiconductors and luminescent materials. Furthermore, a possible mechanism, which involves multiple chelation-assisted ortho CH activation, alkyne insertion, and reductive elimination, is proposed for this transformation.
Palladium-Catalyzed Oxidative Insertion of Carbon Monoxide to N-Sulfonyl-2-aminobiaryls through C-H Bond Activation: Access to Bioactive Phenanthridinone Derivatives in One Pot
(2013-04-05)
Rajeshkumar, Venkatachalam
;
Lee, Tai-Hua
;
Chuang, Shih-Ching
;
應用化學系
;
Department of Applied Chemistry
Palladium-catalyzed oxidative carbonylation of N-sulfonyl-2-aminobiaryls through C-H bond activation and C-C, C-N bond formation under TFA-free and milder conditions has been developed. The reaction tolerates a variety of substrates and provides biologically important phenanthrldlnone derivatives in yields up to 94%.