Browsing by Author "Lee, Tsung-Han"

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Demographics of Pediatric OHCA Survivors With Postdischarge Diseases: A National Population-Based Follow-Up Study
(2020-01-24)
Lee, Tsung-Han
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Juan, I-Cheng
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Hsu, Hsiu-Ying
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Chen, Wen-Liang
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Huang, Cheng-Chieh
Background: Postdischarge diseases (PDDs) have been reported for adult survivors of out-of-hospital cardiac arrest (OHCA). However, the detailed demographics of pediatric OHCA survivors with PDDs are not well-documented, and information regarding functional survivors is particularly limited. We aimed to report detailed information on the PDDs of survivors of traumatic and non-traumatic pediatric OHCA using a national healthcare database. Methods: We retrospectively obtained data from the Taiwan government healthcare database (2011-2015). Information on the demographics of traumatic and non-traumatic pediatric OHCA survivors (<20 years) was obtained and reported. The patients who survived to discharge (survivors) and those classified as functional survivors were followed up for 1 year for the analysis of newly diagnosed PDDs. The time from discharge to PDD diagnosis was also reported. Results: A total of 2,178 non-traumatic and 288 traumatic OHCA pediatric cases were included. Among the non-traumatic OHCA survivors (n = 374, survival rate = 17.2%), respiratory tract (n = 270, 72.2%), gastrointestinal (n = 187, 50.0%), and neurological diseases (n = 167, 49.1%) were the three most common PDD categories, and in these three categories, the majority of PDDs were atypical/influenza pneumonia, non-infective acute gastroenteritis, and generalized/status epilepsy, respectively. Among the traumatic OHCA survivors (n = 21, survival rate = 7.3%), respiratory tract diseases (n = 17, 81.0%) were the most common, followed by skin or soft tissue (n = 14, 66.7%) diseases. Most functional survivors still suffered from neurological and respiratory tract diseases. Most PDDs, except for skin or soft tissue diseases, were newly diagnosed within the first 3 months after discharge. Conclusions: Respiratory tract (pneumonia), neurological (epilepsy), and skin or soft tissue (dermatitis) diseases were very common among both non-traumatic and traumatic OHCA survivors. More importantly, most PDDs, except for skin or soft tissue diseases, were newly diagnosed within the first 3 months after discharge.
Early Epinephrine Improves the Stabilization of Initial Post-resuscitation Hemodynamics in Children With Non-shockable Out-of-Hospital Cardiac Arrest
(2019-06-06)
Lin, Yan-Ren
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Li, Chao-Jui
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Huang, Cheng-Chieh
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Lee, Tsung-Han
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Chen, Tren-Yi
Background: In children with non-shockable out-of-hospital cardiac arrest, early epinephrine (EE) might help to establish the return of spontaneous circulation (ROSC) and be associated with survival. In the present study, we aimed to analyze the effects of EE on outcomes and post-resuscitation hemodynamics in children with non-shockable OHCA. Methods: This was a retrospective analysis of data from 216 children (<19 years) who had suffered non-traumatic and non-shockable OHCA and received epinephrine for resuscitation (Jan 1, 2006-Dec 31, 2014). Demographics, pre-/in-hospital information, and the time to the first dose of epinephrine were recorded. Early post-resuscitation hemodynamics (the first hour after sustained ROSC), survival and good neurological outcomes (Pediatric Cerebral Performance Category Scales 1 or 2) were analyzed by the time to epinephrine-classified as early (EE): <15 min, intermediate (IE): 15-30 min, or late (LE): >30 min. Results: Twenty-eight (13.0%) children survived to discharge, but only 17 (7.9%) had good neurological outcomes. In all, 41 (18.9%) children received EE; in comparison to IE and LE, this was significantly associated with tachycardia (73.9%) in the post-resuscitation period (p < 0.05). Tachycardia (OR: 7.41, 95% CI: 1.96-29.31) and hypertension (OR: 6.03, 95% CI: 1.85-13.77) were significantly associated with EE after adjusting for confounding factors. EE was also significantly associated with better overall outcomes than ME and LE (any ROSC, sustained ROSC, survival to the intensive care unit, admission, survival to discharge and good neurological outcomes, all p < 0.05). Conclusions: EE helped to establish ROSC but was also associated with more tachycardia and hypertension in the early post-resuscitation period. In children with non-traumatic and non-shockable OHCA, EE was associated with a higher survival rate and better neurological outcomes than were ME and LE.
Electricity Generation Using Biogas From Swine Manure for Farm Power Requirement
(2015-01-01)
Chang, Chia-Wei
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Lee, Tsung-Han
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Lin, Wei-Tsung
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Chen, Chiun-Hsun
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機械工程學系
This study conducted 30 kW-generator experiments at a small biogas plant on a swine farm to serve as a preliminary study for the construction of a 300-kW power plant for a larger scale biogas plant in the near future. The experimental results showed that the optimum biogas flow rate for the engine was around 240 to 260 L/min, and the maximum power generation, the corresponding thermal efficiency, and the percentage of consumed CH4 were 26.8 kW, 28.7%, and 95.4%, respectively, at a biogas supply rate of 260 L/min. With 3% oxygen-enriched air, the maximum power generation, thermal efficiency, and percentage of consumed CH4 increased up to 28.2 kW, 30.2%, and approximately 100%, respectively, for a biogas supply rate of 260 L/min, and the engine can operate normally at a lower limited fuel supply rate of 220 L/min. The heat exchanger could recover 923 kJ/min of heat from the flue gas, leading to an overall efficiency of 47.3%, at a biogas supply rate of 240 L/min. With the total swine population (around 4.3 million heads) from the farm scale of over 1,000 heads of pigs in Taiwan, the estimation, based on the data obtained from this study, shows the economic benefits of using biogas, including an annual electricity generation of 2.67 x 10(8) kWh(e) (corresponding to electricity charge savings of US$ 26.7 million), where natural gas charge savings total US$ 8.7 million, and the carbon dioxide reduction totals 180,000 tons.
Improving the reproducibility, accuracy, and stability of an electrochemical biosensor platform for point-of-care use
(2020-05-01)
Chen, Lung-Chieh
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Wang, Erick
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Tai, Chun-San
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Chiu, Yuan-Chen
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Li, Chang-Wei
Electrochemical biosensors possess numerous desirable qualities for target detection, such as portability and ease of use, and are often considered for point-of-care (POC) development. Label-free affinity electrochemical biosensors constructed with semiconductor manufacturing technology (SMT)-produced electrodes and a streptavidin biomediator currently display the highest reproducibility, accuracy, and stability in modern biosensors. However, such biosensors still do not meet POC guidelines regarding these three characteristics. The purpose of this research was to resolve the limitations in reproducibility and accuracy caused by problems with production of the biosensors, with the aim of developing a platform capable of producing devices that exceed POC standards. SMT production settings were optimized and bioreceptor immobilization was improved through the use of a unique linker, producing a biosensor with exceptional reproducibility, impressive accuracy, and high stability. Importantly, the three characteristics of the sensors produced using the proposed platform all meet POC standards set by the Clinical and Laboratory Standards Institute (CLSI). This suggests possible approval of the biosensors for POC development. Furthermore, the detection range of the platform was demonstrated by constructing biosensors capable of detecting common POC targets, including circulating tumor cells (CTCs), DNA/RNA, and curcumin, and the devices were optimized for POC use. Overall, the platform developed in this study shows high potential for production of POC biosensors.
Significant predictive factors of the severity and outcomes of the first attack of acute angioedema in children
(2019-11-11)
Syue, Yuan-Jhen
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Li, Chao-Jui
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Chen, Wen-Liang
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Lee, Tsung-Han
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Huang, Cheng-Chieh
Background The initial episode of angioedema in children can be potential life-threatening due to the lack of prompt identification and treatment. We aimed to analyze the factors predicting the severity and outcomes of the first attack of acute angioedema in children. Methods This was a retrospective study with 406 children (< 18 years) who presented in the emergency department (ED) with an initial episode of acute angioedema and who had subsequent follow-up visits in the out-patient department from January 2008 to December 2014. The severity of the acute angioedema was categorized as severe (requiring hospital admission), moderate (requiring a stay in the short-term pediatric observation unit [POU]), or mild (discharged directly from the ED). The associations among the disease severity, patient demographics and clinical presentation were analyzed. Result In total, 109 (26.8%) children had severe angioedema, and the majority of those children were male (65.1%). Most of the children were of preschool age (56.4%), and only 6.4% were adolescents. The co-occurrence of pyrexia or urticaria, etiologies of the angioedema related to medications or infections, the presence of respiratory symptoms, and a history of allergies (asthma, allergic rhinitis) were predictors of severe angioedema (all p < 0.05). Finally, the duration of angioedema was significantly shorter in children who had received short-term POU treatment (2.1 +/- 1.1 days) than in those who discharged from ED directly (2.3 +/- 1.4 days) and admitted to the hospital (3.5 +/- 2.0 days) (p < 0.001). Conclusion The co-occurrence of pyrexia or urticaria, etiologies related to medications or infections, the presence of respiratory symptoms, and a history of allergies were predictors of severe angioedema. More importantly, short-term POU observation and prompt treatment might be benefit for patients who did not require hospital admission.
The experimental study on biogas power generation enhanced by using waste heat to preheat inlet gases
(2013-02-01)
Lee, Tsung-Han
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Huang, Sheng-Rung
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Chen, Chiun-Hsun
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機械工程學系
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Department of Mechanical Engineering
A 30 kW generator at the Taiwan Sugar Swine Farm in Taichung was used to collect data intended for long-term electricity generation. This three-part experimental study utilized a biogas with a 73% methane concentration. First, the effect of the biogas supply rate on generator performance at different excess air ratios is investigated. Second, the results from this study are compared with results obtained from work performed on a biogas with a 60% methane concentration. Finally, for a 73% methane concentration biogas, the effect on generator performance of preheating the inlet gas to different temperatures is investigated by applying a waste-heat recovery system. Power generation increases with increasing biogas methane concentration, except when A (excess air ratio) < similar to 0.85. However, thermal efficiency increases with increasing methane concentration only when lambda > similar to 0.95, although on the relatively rich side (lambda < 0.95), there is no benefit. The improved generator performance obtained by preheating the inlet gas is apparent when the excess air ratio is relatively high, such as when lambda > 1.3. (C) 2012 Elsevier Ltd. All rights reserved.
The Impact of Emergency Interventions and Patient Characteristics on the Risk of Heart Failure in Patients with Nontraumatic OHCA
(2019-12-16)
Chen, Cheng Hsu
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Chang, Chih-Yu
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Yang, Mei-Chueh
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Wu, Jr-Hau
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Liao, Ching-Hui
Background. Since out-of-hospital cardiac arrest- (OHCA-) related dysfunction (ischemic/reperfusion injury and inflammatory response) might result in long-term impairment, we suspect that new-onset heart failure might be common in long-term survivors. However, these relationships had not been well addressed, and we aimed to analyze the impact of emergency interventions and patient characteristics on the risk of new-onset heart failure in patients with nontraumatic OHCA. Methods. The Taiwanese government healthcare database contains data for 49,101 nontraumatic OHCA adult patients from 2011-2012, which were analyzed in this study. Nontraumatic OHCA patients who survived to the intensive care unit (ICU) were included as the study group (n = 7,321). Matched patients (n = 21,963) were recruited as a comparison group. Patients with any history of heart failure or cardiac arrest were not included in either group. All patients were followed-up for 6 months for the identification of new-onset heart failure. Adjustments were made for demographics, age, emergency interventions, and comorbidities as potential risk factors. Results. In all, 3.84% (n = 281) of OHCA patients suffered new-onset heart failure, while only 1.24% (n = 272) of matched patients in the comparison group suffered new-onset heart failure. Strong risk factors for heart failure were age (60-75 years, HR: 11.4; 95% CI: 9-14.4), medical history (myocardial infarction, HR: 2.47; 95% CI: 2.05-2.98 and cardiomyopathy, HR: 2.94; 95% CI: 1.45-5.94), and comorbidities during hospitalization (ischemic heart disease, HR: 4.5; 95% CI: 3.46-5.86). Only extracorporeal membrane oxygenation (ECMO) decreased the risk of heart failure. Most (53.6%) heart failure events occurred within 60 days after OHCA. Conclusion. An age from 61 to 75 years, a history of myocardial infarction or cardiomyopathy, and ischemic heart disease or infection as comorbidities occurring during hospitalization were strong risk factors for new-onset heart failure in OHCA patients. However, ECMO could decrease this risk. More importantly, most heart failure events occurred within 60 days after OHCA.
Tunable Fano-Kondo resonance in side-coupled double quantum dot systems
(2010-08-26)
Chung, Chung-Hou
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Lee, Tsung-Han
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電子物理學系
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Department of Electrophysics
We study the interference between the Fano and Kondo effects in a side-coupled double quantum dot system where one of the quantum dots couples to conduction-electron bath while the other dot only side couples to the first dot via antiferromagnetic (AF) spin-exchange coupling. We apply both the perturbative renormalization-group (RG) and numerical renormalization-group (NRG) approaches to study the effect of AF coupling on the Fano line shape in the conduction leads. With particle-hole symmetry, the AF spin-exchange coupling competes with the Kondo effect and leads to a local spin-singlet ground state for arbitrary small coupling, so-called "two-stage Kondo effect." As a result, via NRG we find the spectral properties of the Fano line shape in the tunneling density of states rho(c)(omega) of conduction-electron leads shows double dip-peak features at the energy scale around the Kondo temperature and the one much below it, corresponding to the two-stage Kondo effect; it also shows an universal scaling behavior at very low energies. We find the qualitative agreement between the NRG and the perturbative RG approaches. Relevance of our work to the experiments is discussed.
Universal scaling of nonlinear conductance in the two-channel pseudogap Anderson model: Application for gate-tuned Kondo effect in magnetically doped graphene
(2013-08-26)
Lee, Tsung-Han
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Zhang, Kenneth Yi-Jie
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Chung, Chung-Hou
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Kirchner, Stefan
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電子物理學系
Based on the noncrossing approximation, we calculate both the linear and nonlinear conductance within the two-lead two-channel single-impurity Anderson model where the conduction electron density of states vanishes in a power-law fashion proportional to vertical bar omega - mu(F)vertical bar(r) with r = 1 near the Fermi energy, appropriate for a hexagonal system. For given gate voltage, we address the universal crossover from a two-channel Kondo phase, argued to occur in doped graphene, to an unscreened local moment phase. We extract universal scaling functions in conductance governing charge transfer through the two-channel pseudogap Kondo impurity and discuss our results in the context of a recent scanning tunneling spectroscopy experiment on Co-doped graphene.
Use High-Flow Nasal Cannula for Acute Respiratory Failure Patients in the Emergency Department: A Meta-Analysis Study
(2019-10-13)
Huang, Cheng-Chieh
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Lan, Hao-Min
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Li, Chao-Jui
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Lee, Tsung-Han
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Chen, Wen-Liang
Objective. To evaluate the efficacy of high-flow nasal cannula (HFNC) therapy compared with conventional oxygen therapy (COT) or noninvasive ventilation (NIV) for the treatment of acute respiratory failure (ARF) in emergency departments (EDs). Method. We comprehensively searched 3 databases (PubMed, EMBASE, and the Cochrane Library) for articles published from database inception to 12 July 2019. This study included only randomized controlled trials (RCTs) that were conducted in EDs and compared HFNC therapy with COT or NIV. The primary outcome was the intubation rate. The secondary outcomes were the mortality rate, intensive care unit (ICU) admission rate, ED discharge rate, need for escalation, length of ED stay, length of hospital stay, and patient dyspnea and comfort scores. Result. Five RCTs (n = 775) were included. There was a decreasing trend regarding the application of HFNC therapy and the intubation rate, but the difference was not statistically significant (RR, 0.53; 95% CI, 0.26-1.09; p=0.08; I-2 = 0%). We found that compared with patients who underwent COT, those who underwent HFNC therapy had a reduced need for escalation (RR, 0.41; 95% CI, 0.22-0.78; p=0.006; I-2 = 0%), reduced dyspnea scores (MD -0.82, 95% CI -1.45 to -0.18), and improved comfort (SMD -0.76 SD, 95% CI -1.01 to -0.51). Compared with the COT group, the HFNC therapy group had a similar mortality rate (RR, 1.25; 95% CI, 0.79-1.99; p=0.34; I-2 = 0%), ICU admission rate (RR, 1.11; 95% CI, 0.58-2.12; p=0.76; I-2 = 0%), ED discharge rate (RR, 1.04; 95% CI, 0.63-1.72; p=0.87; I-2 = 0%), length of ED stay (MD 1.66, 95% CI -0.95 to 4.27), and hospital stay (MD 0.9, 95% CI -2.06 to 3.87). Conclusion. Administering HFNC therapy in ARF patients in EDs might decrease the intubation rate compared with COT. In addition, it can decrease the need for escalation, decrease the patient's dyspnea level, and increase the patient's comfort level compared with COT.