Browsing by Author "Lee, Wei-Chih"

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Nickel promoted switchable hydroheteroarylation of cyclodienes via C-H bond activation of heteroarenes
(2015-07-01)
Lee, Wei-Chih
;
Shih, Wei-Chin
;
Wang, Ting-Hsuan
;
Liu, Yuhua
;
Yap, Glenn P. A.
We demonstrated Ni-catalyzed switchable hydroheteroarylation of cyclic dienes via C-H bond activation of heteroarenes. In the presence of an N-heterocyclic carbene (NHC) ligand, hydroheteroarylation of cyclic diene with azole afforded alpha-alkenyl-azole, forging a Heck-like product without using any external oxidant. Conversely, changing the ligand to PCy3 would switch this reaction manifold to afford the other isomeric beta-alkenyl substituted azole. (C) 2015 Elsevier Ltd. All rights reserved.
Nickel-catalysed para-CH activation of pyridine with switchable regioselective hydroheteroarylation of allylarenes
(2015-01-01)
Lee, Wei-Chih
;
Chen, Chien-Hung
;
Liu, Cheng-Yuan
;
Yu, Ming-Shiuan
;
Lin, Yung-Huei
para-CH activation of pyridine with allylbenzene is described by Ni/Al cooperative catalysis in combination with a bulkier NHC ligand and a Lewis acid, leading to linear hydroheteroarylation products. Interestingly, the branch selectivity can be achieved by using the combination of a less sterically hindered amino-NHC ligand and AlMe3 through tandem reaction of facile alkene isomerization followed by a slow CH bond activation process.
Tandem Isomerization and C-H Activation: Regioselective Hydroheteroarylation of Allylarenes
(2013-10-18)
Lee, Wei-Chih
;
Wang, Chun-Han
;
Lin, Yung-Huei
;
Shih, Wei-Chun
;
Ong, Tiow-Gan
The first Ni-promoted prototype reaction based on the tandem C-H activation of heteroarenes with alkene isomerization is demonstrated, leading to the branched hydroheteroarylation products. Simultaneously, the reaction selectivity can be chemically switched to linear adducts through Ni-Al tandem catalysis.