Browsing by Author "Li, Yu-Cheng"

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Landscape of Mitochondria Genome and Clinical Outcomes in Stage 1 Lung Adenocarcinoma
(2020-03-01)
Raghav, Lovely
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Chang, Ya-Hsuan
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Hsu, Yi-Chiung
;
Li, Yu-Cheng
;
Chen, Chih-Yi
Risk factors including genetic effects are still being investigated in lung adenocarcinoma (LUAD). Mitochondria play an important role in controlling imperative cellular parameters, and anomalies in mitochondrial function might be crucial for cancer development. The mitochondrial genomic aberrations found in lung adenocarcinoma and their associations with cancer development and progression are not yet clearly characterized. Here, we identified a spectrum of mitochondrial genome mutations in early-stage lung adenocarcinoma and explored their association with prognosis and clinical outcomes. Next-generation sequencing was used to reveal the mitochondrial genomes of tumor and conditionally normal adjacent tissues from 61 Stage 1 LUADs. Mitochondrial somatic mutations and clinical outcomes including relapse-free survival (RFS) were analyzed. Patients with somatic mutations in the D-loop region had longer RFS (adjusted hazard ratio, adjHR = 0.18, p = 0.027), whereas somatic mutations in mitochondrial Complex IV and Complex V genes were associated with shorter RFS (adjHR = 3.69, p = 0.012, and adjHR = 6.63, p = 0.002, respectively). The risk scores derived from mitochondrial somatic mutations were predictive of RFS (adjHR = 9.10, 95%CI: 2.93-28.32, p < 0.001). Our findings demonstrated the vulnerability of the mitochondrial genome to mutations and the potential prediction ability of somatic mutations. This research may contribute to improving molecular guidance for patient treatment in precision medicine.
Little Hero Wins the Masks Virtual Reality Creation of Taiwanese Classic Comics
(2018-01-01)
Hsu, Chun-Cheng
;
Lee, Chun-I
;
Li, Yu-Cheng
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應用藝術研究所
;
Institute of Applied Arts
Taiwanese comics artist Hung-Chia Yeh created martial arts comic series "Little Hero" in 1958. Little Hero was later super famous in 1960s. However, Taiwanese comics culture has declined due to various historical background, which caused younger generation know little about Taiwanese comics. We did this derivative work with VR and AR technology based on one of the classic story in Little Hero called "Little Hero Wins the Masks" The features of this work are: (1) Develop the technology that connect VR and interactive game table together to improve the insufficiency of sociability in VR games; (2) The feedback of handheld controller and the game card of interactive game table are designed to improve interactivity in the game (See Figure 1).