Browsing by Author "Liang, Min-Chieh"

Now showing 1 - 2 of 2

A Combined Tamaru Allylation/Olefin Cross-Metathesis Approach for the Total Syntheses of (+/-)-Paniculidine B, (+/-)-Paniculidine C, and 2-Methylcarbazole
(2018-03-01)
Tseng, Yi-Lun
;
Liang, Min-Chieh
;
Chen, I-Chia
;
Wu, Yen-Ku
;
應用化學系
A concise approach to the total syntheses of racemic paniculidines B and C is described. The route features a combined Tamaru allylation/olefin cross-metathesis sequence for the regiocontrolled synthesis of prenylindole intermediates. In addition, we report a transformation of the prenylated indole into 2-methylcarbazole catalyzed by sulfonic acid-functionalized silica gel.
Temperature-Controlled Thiation of alpha-Cyano-beta-Alkynyl Carbonyl Derivatives for De Novo Synthesis of 2-Aminothiophenes and Thieno[2,3-c]isothiazoles
(2018-12-07)
Kao, Tzu-Ting
;
Peng, Bo-Kai
;
Liang, Min-Chieh
;
Lee, Chia-Jui
;
Chen, I-Chia
Making use of temperature-controlled thiation as a key operation, a simple route to 2-aminothiophenes or thieno[2,3-c]isothiazoles has been newly developed wherein the 2-aminothiophene nucleus was formed through an initial formation of thioamide followed by a 5-exo-dig addition to the tethered alkyne; however, under harsher thermal conditions, excess sulfur-transferring reagents enabled further oxidative thiation to generate the corresponding thieno[2,3-c]isothiazoles.