Browsing by Author "Lin, Chih-Peng"

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A Miniaturized Wide Band Micromachined Directional Coupler
(2010-01-01)
Lin, Chih-Peng
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Li, Yung-Hsiu
;
Jou, Christina F.
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交大名義發表
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National Chiao Tung University
In this paper, a miniaturized wide band micromachined directional coupler is demonstrated. A slot structure is applied to the design and utilized to enhance the coupling between the signal lines, therefore, the proposed coupler can achieve high coupling within a smaller area. The overall size of the proposed coupler is only 1340 x 4750 gm. The final dimensions are obtained with the use of full-wave electromagnetic analysis. The validity of the proposed design is confirmed experimentally.
A Novel Transition for a Half-Mode Substrate Integrated Waveguide Leaky Wave Antenna
(2011)
Huang, Jie-Huang
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Lu, Jeng-Hau
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Lin, Chih-Peng
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Jou, Christina F.
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電信工程研究所
A novel transition structure of the half mode substrate integrated leaky wave antenna has been proposed in this paper. The transition structure can efficiently convert the input power to the leaky mode to enhance the efficiency of the leaky wave antenna and avoid possible reflection at the terminal of the leaky wave antenna. Moreover, a modified method of complex propagation constants extraction for leaky wave antenna is also presented in this paper, which gives accurate prediction on the radiation performance of the leaky wave antenna. Measured and simulated results indicate that the proposed transition structure makes the side lobe of the half mode substrate integrated leaky wave antenna smaller.
A novel ultra wideband transformer-feedback LNA
(2008)
Wu, Hui I.
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Lin, Tsung-Ting
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Jou, Christina F.
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Lin, Chih-Peng
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Chiang, Pei-Yuan
A 3-10 GHz wide-band low noise amplifier with novel input matching mechanism is presented in this letter. The proposed circuit uses reactive-feedback and transistor's intrinsic gate-drain capacitor as input matching network to achieve a simulated -10dB input reflection coefficient from 3.1 GHz to 10.6 GHz. The fabricated wideband LNA achieves a simulated power gain (S21) of about 10 dB from 3.1 G to 10.6 GHz, and noise figure of 2.72-3.26 dB from 3.1 G to 10.6 GHz. The input 1 dB compression point and input IP3 (IIP3) at 3.1 GHz are about -18.5 and -12 dBm, respectively. The DC supply voltage and power consumption is 1.5V(-) and 15 mA, respectively.
COMPACT QUAD BAND MONOPOLE ANTENNA
(2011-06-01)
Lin, Chih-Peng
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Chang, Chieh-Hsiang
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Jou, Christina F.
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電信工程研究所
;
Institute of Communications Engineering
In this article, a compact quad band monopole antenna is demonstrated. Asymmetric coplanar strip feeding is applied in the design in order to compact the size. The proposed antenna fabricated on a FR4 substrate has an overall size of 30-30 mm(2). By integrating an invert-C slot and a modified invert-F strip into an invert-C patch, multiple resonant frequencies can be excited at 1.1, 2.35, 3.6, and 5.4 GHz individually for global positioning system, wireless local area network, Bluetooth/ISM, and Wi-MAX applications. The measured result has shown a good agreement with the simulation results. (C) 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:1272-1276, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25994
COMPACT QUAD BAND MONOPOLE ANTENNA
(2011-06-01)
Lin, Chih-Peng
;
Chang, Chieh-Hsiang
;
Jou, Christina F.
;
交大名義發表
;
National Chiao Tung University
In this article, a compact quad band monopole antenna is demonstrated. Asymmetric coplanar strip feeding is applied in the design in order to compact the size. The proposed antenna fabricated on a FR4 substrate has an overall size of 30-30 mm(2). By integrating an invert-C slot and a modified invert-F strip into an invert-C patch, multiple resonant frequencies can be excited at 1.1, 2.35, 3.6, and 5.4 GHz individually for global positioning system, wireless local area network, Bluetooth/ISM, and Wi-MAX applications. The measured result has shown a good agreement with the simulation results. (C) 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:1272-1276, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25994
Deriving protein dynamical properties from weighted protein contact number
(2008-08-15)
Lin, Chih-Peng
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Huang, Shao-Wei
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Lai, Yan-Long
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Yen, Shih-Chung
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Shih, Chien-Hua
It has recently been shown that in proteins the atomic mean-square displacement (or B-factor) can be related to the number of the neighboring atoms (or protein contact number), and that this relationship allows one to compute the B-factor profiles directly from protein contact number. This method, referred to as the protein contact model, is appealing, since it requires neither trajectory integration nor matrix diagonalization. As a result, the protein contact model can be applied to very large proteins and can be implemented as a high-throughput computational toot to compute atomic fluctuations in proteins. Here, we show that this relationship can be further refined to that between the atomic mean-square displacement and the weighted protein contact-number, the weight being the square of the reciprocal distance between the contacting pair. In addition, we show that this relationship can be utilized to compute the cross-correlation of atomic motion (the B-factor is essentially the auto-correlation of atomic motion). For a nonhomologous dataset comprising 972 high-resolution X-ray protein structures (resolution < 2.0 angstrom and sequence identity < 25%), the mean correlation coefficient between the X-ray and computed B-factors based on the weighted protein contact-number model is 0.61, which is better than those of the original contact-number model (0.51) and other methods. We also show that the computed correlation maps based on the weighted contact-number model are globally similar to those computed through normal model analysis for some selected cases. Our results underscore the relationship between protein dynamics and protein packing. We believe that our method will be useful in the study of the protein structure-dynamics relationship.
Development of a Flexible SU-8/PDMS-Based Antenna
(2011)
Lin, Chih-Peng
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Chang, Chieh-Hsiang
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Cheng, Y. T.
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Jou, Christina F.
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電信工程研究所
In this letter, a flexible SU-8/PDMS-based antenna has been demonstrated, not only targeting the wearable computing, but also fitting well in the RF system-on-package (RF SOP) applications. The characteristics of the proposed antenna fabricated on a flexible polymer substrate (SU-8/PDMS) with different bending angles have been successfully measured and characterized for the first time. The measured results have shown fairly good agreement with the simulation results. The measured bandwidth and maximum gain are 3% from 6.2 to 6.4 GHz and 2.17 dBi, respectively, when the antenna is flat. Moreover, related antenna fabrication process provides a practical approach to realize the flexible antenna for the portable wireless electronics applications.
Hepatocellular carcinoma-associated single-nucleotide variants and deletions identified by the use of genome-wide high-throughput analysis of hepatitis B virus
(2017-10-01)
Liu, Wen-Chun
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Wu, I-Chin
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Lee, Yen-Chien
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Lin, Chih-Peng
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Cheng, Ji-Hong
This study investigated hepatitis B virus (HBV) single-nucleotide variants (SNVs) and deletion mutations linked with hepatocellular carcinoma (HCC). Ninety-three HCC patients and 108 non-HCC patients were enrolled for HBV genome-wide next-generation sequencing (NGS) analysis. A systematic literature review and a meta-analysis were performed to validate NGS-defined HCC-associated SNVs and deletions. The experimental results identified 60 NGS-defined HCC-associated SNVs, including 41 novel SNVs, and their pathogenic frequencies. Each SNV was specific for either genotype B (n = 24) or genotype C (n = 34), except for nt53C, which was present in both genotypes. The pathogenic frequencies of these HCC-associated SNVs showed a distinct U-shaped distribution pattern. According to the meta-analysis and literature review, 167 HBV variants from 109 publications were categorized into four levels (A-D) of supporting evidence that they are associated with HCC. The proportion of NGS-defined HCC-associated SNVs among these HBV variants declined significantly from 75% of 12 HCC-associated variants by meta-analysis (Level A) to 0% of 10 HCC-unassociated variants by meta-analysis (Level D) (P < 0.0001). PreS deletions were significantly associated with HCC, in terms of deletion index, for both genotypes B (P = 0.030) and C (P = 0.049). For genotype C, preS deletions involving a specific fragment (nt2977-3013) were significantly associated with HCC (HCC versus non-HCC, 6/34 versus 0/32, P = 0.025). Meta-analysis of preS deletions showed significant association with HCC (summary odds ratio 3.0; 95% confidence interval 2.3-3.9). Transfection of Huh7 cells showed that all of the five novel NGS-defined HCC-associated SNVs in the small surface region influenced hepatocarcinogenesis pathways, including endoplasmic reticulum-stress and DNA repair systems, as shown by microarray, real-time polymerase chain reaction and western blot analysis. Their carcinogenic mechanisms are worthy of further research. Copyright (c) 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
New CMOS-Compatible Micromachined Embedded Coplanar Waveguide
(2010-09-01)
Lin, Chih-Peng
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Jou, Christina F.
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電信工程研究所
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Institute of Communications Engineering
This paper proposes a new robust micromachined embedded coplanar waveguide (CPW). The central and ground plates are partially bent and overlapped within the trench, and due to tight coupling of the E-field between the overlapped plates, the micromachined embedded CPW line is capable of a wide range characteristic impedance 17.9-92.3 Omega), in a compact size. Furthermore, the area in which the E-field radiates into the substrate of the micromachined embedded CPW is quite narrow compared to conventional CPWs, and therefore, the dielectric loss of the micromachined embedded CPW can be effectively suppressed. Compared with conventional CPW lines, the embedded CPW lines have shown a marked reduction in loss, especially in the low-impedance range. The micromachined embedded CPW lines on the high-resistivity silicon substrate (rho(s) = 15 000 Omega . cm))achieve a measured loss as low as 0.81 dB/cm at 50 GHz. Moreover, the fabrication process of the micromachined embedded CPW line is compatible with the CMOS process. These features make micromachined embedded CPW a promising transmission line for RF integrated circuit application.
On the relationship between the protein structure and protein dynamics
(2008-08-01)
Lu, Chih-Hao
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Huang, Shao-Wei
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Lai, Yan-Long
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Lin, Chih-Peng
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Shih, Chien-Hua
Recently, we have developed a method (Shih et al., Proteins: Structure, Function, and Bioinformatics 2007,68: 34-38) to compute correlation of fluctuations of proteins. This method, referred to as the protein fixed-point (PFP) model, is based on the positional vectors of atoms issuing from the fixed point, which is the point of the least fluctuations in proteins. One corollary from this model is that atoms lying on the same shell centered at the fixed point will have the same thermal fluctuations. In practice, this model provides a convenient way to compute the average dynamical properties of proteins directly from the geometrical shapes of proteins without the need of any mechanical models, and hence no trajectory integration or sophisticated matrix operations are needed. As a result, it is more efficient than molecular dynamics simulation or normal mode analysis. Though in the previous study the PFP model has been successfully applied to a number of proteins of various folds, it is not clear to what extent this model will be applied. In this article, we have carried out the comprehensive analysis of the PFP model for a dataset comprising 972 high-resolution X-ray structures with pairwise sequence identity <= 25%. We found that in most cases the PFP model works well. However, in case of proteins comprising multiple domains, each domain should be treated separately as an independent dynamical module with its own fixed point, and in case of the protein complex comprising it number of subunits, if functioning as a biological unit, the whole complex should be considered as one single dynamical module with one fixed point. Under such considerations, the resultant correlation coefficient between the computed and the X-ray structural B-factors for the data set is 0.59 and 75% (727/972) of proteins with a correlation coefficient >= 0.5. Our result shows that the fixed-point model is indeed quite general and will be a useful tool for high throughput analysis of dynamical properties of proteins.
Prediction of NMR order parameters in proteins using weighted protein contact-number model
(2008-10-01)
Huang, Shao-Wei
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Shih, Chien-Hua
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Lin, Chih-Peng
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Hwang, Jenn-Kang
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生物資訊及系統生物研究所
In the NMR experiment, the protein backbone motion can be described by the N-H order parameters. Though protein dynamics is determined by a complex network of atomic interactions, we show that the order parameter of residues can be determined using a very simple method, the weighted protein contact number model. We computed for each C alpha atom the number of neighboring C alpha atoms weighted by the inverse distance squared between them. We show that the weighted contact number of each residue is directly related to its order parameter. Despite the simplicity of this model, it performs better than the other method. Since we can compute the order parameters directly from the topological properties (such as protein contact number) of protein structures, our study underscores a very direct link between protein topological structure and its dynamics.