Browsing by Author "Lin, Chih-Yuan"

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A Rare Experience of Infective Residual Sheath in the Wall of the Innominate Vein after Extraction of Implantable-Defibrillators
(2017-07-01)
Liu, Yuan-Hao
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Lin, Wei-Shiang
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Lin, Yi-Chang
;
Lin, Chih-Yuan
;
Tsai, Chien-Sung
Background: Cardiac device-related infective endocarditis is an uncommon but potentially fatal complication. Therefore, cardiac devices should be removed as soon as a device-related infection is suspected. Case Report: A 56-year-old male with a history of arrhythmogenic right ventricular dysplasia with implantable cardioverter-defibrillators (ICDs) 7 years earlier and re-implantation of ICDs due to dysfunction 18 months ago presented with erosion of the ICD pocket with Pseudomonas bacteremia. For the past year, only multiple wound debridements were performed. Accordingly, we performed debridement and removal of the generator during this admission; however, bacteremia still persisted. Using transesophageal echocardiography, we detected vegetation on the pacing leads and tricuspid valve in the right atrium. We performed thoracotomy with tricuspid valve repair and pacing wire removal. However, anterior chest pain and refractory bacteremia occurred 3 months later after discharge, and an infectious foreign body in the wall of the innominate vein was detected using chest computer tomography. Thoracotomy was again performed for resection of the innominate vein with the infection source. Postoperative recovery was good, with no systemic infection or bacteremia. Conclusions: Pacing lead extraction is a common procedure following cardiac rhythm management device-related infection. However, residual foreign body-related bacteremia should be suspected in cases with fever of unknown origin after primary surgery. Preserving the innominate vein with patch repair is a feasible option. However, a postoperative 4-week course of antibiotics is recommended.
BLOOD MIXING UPREGULATES PLATELET MEMBRANE- BOUND CD40 LIGAND EXPRESSION IN VITRO INDEPENDENT OF ABO COMPATIBILITY
(2018-09-01)
Huang, Go-Shine
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Hu, Mei-Hua
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Lin, Tso-Chou
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Lin, Yi-Chang
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Tsai, Yi-Ting
Platelets play a central role in the inflammation response via CD40 ligand (CD40L) expression, which may lead to transfusion reactions. The precise role of platelet CD40L-mediated inflammation in transfusion reactions is unclear. Therefore, we assessed the effects of in vitro blood mixing on platelet CD40L expression. In addition, we examined the effect of ABO compatibility on CD40L expression. Donor-packed red blood cells were acquired from a blood bank, and recipient blood was obtained from patients undergoing cardiac surgery and prepared as washed platelets. Donor blood was mixed with suspended, washed recipient platelets to obtain a final mixing ratio of 1%, 5%, or 10% (vol/vol). The blood mixtureswere divided into three groups: group M, cross-matched blood-type mixing (n = 20); group S, ABO type-specific uncross-matched blood (n = 20); and group I, ABO incompatibility (not ABO type-specific blood and not process cross-matched) mixing (n = 20). The blood mixtures were used to detect platelet membrane-bound CD40L expression by flow cytometry. Blood mixing resulted in an increase in CD40L expression in group M (P<0.001), group S (P<0.001), and group I (P<0.001). CD40L expression after blood mixing potentially led to a transfusion reaction in each of the groups. There were no differences in CD40L expression among the three groups (P = 0.988) correlated with ABO compatibility or incompatibility. This indicates that the reactions between red blood cell surface antigens and plasma antibodies do not play a role in the induction of CD40L expression.
Blunt injury of popliteal artery
(2019-01-01)
Chang, Jui-Tsung
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Lin, Chih-Yuan
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Tsai, Yi-Ting
;
Lin, Yi-Chang
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生物科技學系
Effusive Tuberculous Pericarditis
(2017-11-01)
Zheng, Xu-Zhi
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Tsai, Yi-Ting
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Lin, Chih-Yuan
;
Tsai, Chien-Sung
;
Lin, Yi-Chang
IMPACT OF BLOOD MIXING AND ABO COMPATIBILITY ON PLATELET-LEUKOCYTE AGGREGATIONS AND PLATELET P-SELECTIN EXPRESSION: AN IN VITRO STUDY
(2018-05-01)
Huang, Go-Shine
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Hu, Mei-Hua
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Lin, Tso-Chou
;
Tsai, Yi-Ting
;
Lin, Chih-Yuan
Effects of blood transfusions on platelet- and leukocyte-related inflammation are unclear. We simulated transfusion using in vitro blood mixing to evaluate platelet-leukocyte aggregations (PLA) and platelet P-selectin expression, and the mechanism of PLA. Donor packed red blood cells (pRBCs) were obtained from a blood bank. Recipient whole blood samples were obtained from patients undergoing cardiac surgery. Blood sample mixtures were divided into four groups: group M, cross-matched blood type mixing; group O, donor type O with other blood type mixing (A, B, or AB); group S, ABO type-specific uncross-matched blood mixing; and group I, ABO incompatibility mixing. Donor pRBCswere added to recipient blood to reach 1%, 5%, and 10% (vol/vol) concentrations. Blood sample mixtures were analyzed to determine the PLA; P-selectin expression; and leukocyte CD11a, CD11b, and CD18 subunits of integrin expression. Analysis of variance tests were used to analyze differences. PLA significantly increased only in groups O and I (P=0.003 and P<0.001). Subpopulations of leukocytes significantly increased in all groups. There were no significant differences among the four groups (P=0.578) in PLA increase. Although there was no significant effect on P-selectin expression (P=1.000) and leukocyte CD11a and CD18 expression (P=0.999, P=0.422) within and between the groups, there was an increase in CD11b expression (P=0.018). Blood mixing can increase PLA, especially in platelet-neutrophil and platelet-monocyte aggregations, possibly through nonhemolytic reactions. The CD11b integrin with CD18 may play a role in the formation of PLA.
Robust constrained-optimization-based linear receiver for high-rate MIMO-OFDM against channel estimation errors
(2007-06-01)
Lin, Chih-Yuan
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Wu, Jwo-Yuh
;
Lee, Ta-Sung
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電信工程研究所
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Institute of Communications Engineering
We consider multi-input multi-output-orthogonal frequency division multiplexing (MIMO-OFDM) transmission in a scenario that the adopted cyclic-prefix (CP) length is shorter than the channel delay spread for boosting data rate and, moreover, the channel parameters are not exactly known but are estimated using the least-squares (LS) training technique. By exploiting the receiver spatial resource, we propose a constrained-optimization-based linear equalizer which can mitigate inter-symbol interference and inter-carrier interference incurred by insufficient CP interval, and is robust against the net detrimental effects caused by channel estimation errors. The optimization problem is formulated in an equivalent unconstrained generalized-sidelobe-canceller (GSC) setup. The channel parameter error is explicitly incorporated into the constraint-free GSC system model through the perturbation technique; this allows us to exploit the presumed LS channel error property for deriving a closed-form solution, and can also facilitate an associated analytic performance analysis. A closed-form approximate signal-to-interference-plus-noise ratio (SINR) expression for the proposed robust scheme is given, and an appealing formula of the achievable SINR improvement over the nonrobust counterpart is further specified. Our analytic results bring out several intrinsic features of the proposed solution. Simulation study confirms the effectiveness of the proposed method and corroborates the predicted SINR results.
Robust Linear Receiver for High-Rate MIMO OFDM under Channel Parameter Mismatch
(2006)
Lin, Chih-Yuan
;
Wu, Jwo-Yuh
;
Lee, Ta-Sung
;
電信工程研究所
;
Institute of Communications Engineering
We consider MIMO-OFDM transmission, in a scenario that the adopted cyclic-prefix (CP) length is shorter than the channel delay spread for boosting data rate and, moreover, the channel parameters are not exactly known but are estimated using the least-squares (LS) training technique. By exploiting the receiver spatial resource, we propose a constrained-optimization based linear equalizer which can mitigate intersymbol interference and inter-carrier interference incurred by insufficient CP interval, and is robust against the net detrimental effects caused by channel estimation errors. The optimization problem is formulated in an equivalent unconstrained generalized-sidelobe-canceller (GSC) setup. The channel parameter error is explicitly incorporated into the constraint-free GSC system model through the perturbation technique; this allows us to exploit the presumed LS channel error property for deriving a closed-form solution. Simulation results confirm the effectiveness of the proposed method.
Robust Receiver Design for MIMO Single-Carrier Block Transmission over Time-Varying Dispersive Channels Against Imperfect Channel Knowledge
(2008-10-01)
Lin, Chih-Yuan
;
Wu, Jwo-Yuh
;
Lee, Ta-Sung
;
電信工程研究所
;
Institute of Communications Engineering
We consider MIMO single-carrier block transmission over time-varying multipath channels, under the assumption that the channel parameters are not exactly known but are estimated via the least-squares training technique. While the channel temporal variation is known to negate the tone-by-tone frequency-domain equalization facility, it is otherwise shown that in the time domain the signal signatures can be arranged into groups of orthogonal components, leading to a very natural yet efficient group-by-group symbol recovery scheme. To realize this figure of merit we propose a constrained-optimization based receiver which also takes into account the mitigation of channel mismatch effects caused by time variation and imperfect estimation. The optimization problem is formulated in an equivalent unconstrained generalized-sidelobe-canceller setup. This enables us to directly model the channel mismatch effect into the system equations through the perturbation technique and, in turn, to further exploit the statistical assumptions on channel temporal variation and estimation errors for deriving a dosed-form solution. Within the considered framework the proposed robust equalizer can be combined with the successive interference cancellation mechanism for further performance enhancement. Flop count evaluation and numerical simulation are used to evidence the advantages of the proposed scheme.
Robust receiver design for MIMO single-carrier block transmission over time-varying dispersive channels against imperfect channel knowledge
(2008-01-01)
Lin, Chih-Yuan
;
Wu, Jwo-Yuh
;
Lee, Ta-Sung
;
電信工程研究所
;
Institute of Communications Engineering
We consider MIMO single-carrier block transmission over time-varying multipath channels, under the assumption that the channel parameters are not exactly known but are estimated via the least-squares training technique. While the channel temporal variation is known to negate the tone-by-tone frequency-domain equalization facility, it is otherwise shown that in the time domain the signal signatures can be arranged into groups of orthogonal components, leading to a very natural yet efficient group-by-group symbol recovery scheme. To realize this figure of merit we propose a constrained-optimization based receiver which also takes into account the mitigation of channel mismatch effects caused by time variation and imperfect estimation. The optimization problem is formulated in an equivalent unconstrained generalized-sidelobe-canceller setup. This enables us to directly model the channel mismatch effect into the system equations through the perturbation technique and, in turn, to further exploit the statistical assumptions on channel temporal variation and estimation errors for deriving a closed-form solution. Within the considered framework the proposed robust equalizer can be further combined with the successive interference cancellation mechanism for further performance enhancement.