Browsing by Author "Lin, LG"

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Synthesis of calix[4]arenes with four different "lower rim" substituents
(1999-04-16)
Shu, CM
;
Chung, WS
;
Wu, SH
;
Ho, ZC
;
Lin, LG
Calix[4]arenes with four different "lower rim" substituents were synthesized following six-step sequences. The first alkyl group (R-1) was introduced using R1X and CH3ONa, and then reaction with R2X and K2CO3 led to the introduction of a second alkyl group (R-2) at the 3-position. Benzoate was introduced as a protecting group at the 1,3-O-disubstituent stage and was removed under basic conditions after the incorporation of the third alkyl group (R-3) With R3X and NaH, The final alkyl group (R-4) was introduced with R4X and NaH to give the chiral title compounds.