Browsing by Author "Lin, Tsung-Han"

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Design of the channel allocation procedure of the IEEE 802.11 ad-hoc networks for traffic control systems
(2006)
Lin, Tsung-Han
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Wang, B. C.
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Hsu, Pau-Lo
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電控工程研究所
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Institute of Electrical and Control Engineering
The multi-agent traffic control system is a popular topic in intelligent transportation systems (ITS). Considering the cost of deploying wired networks in real world, the wireless network is more convenient in implementation and it is also more appropriate to serve as the communication interface in the multi-agent traffic control system. In this paper, we propose a new method called the channel allocation procedure (CAP) and its physical protocol of IEEE 802.11 ad-hoc network is further modified to suit the hopping procedure for each single channel sequentially. By combining both the proposed CAP method and the ad-hoc on-demand distance vector routing (AODV), an effective communication interface for the multi-agent traffic control system can be thus directly established. The CAP method solves the hidden terminal problem which is the main cause of the degradation of network throughput. By evaluating the CAP method using the NCTUns network simulator, results indicate that the throughput of proposed CAP method increases by 75% to 2300% compared with that of the original 802.11 ad-hoc networks.
Helicobacter pylori-derived heat shock protein 60 increases the induction of regulatory T-cells associated with persistent infection
(2018-06-01)
Hsu, Wei-Tung
;
Ho, Shu-Yi
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Jian, Ting-Yan
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Huang, Han-Ning
;
Lin, Yu-Ling
Local Treg responses are involved in Helicobacter pylori-related inflammation and clinical outcomes after infection, and H. pylori-derived HSP60 (HpHSP60) is an important virulence factor associated with gastric carcinogenesis. This study to investigate the role of HpHSP60 in immunosuppression, particularly with regard to whether it could induce the production of Treg cells. For this purpose, human peripheral blood mononuclear cells (PBMCs) were treated with or without HpHSP60 in the presence of an anti-CD3 mAb to determine the effect of HpHSP60 on cell proliferation. In this report, HpHSP60 decreased the expression of CDK4 to significantly arrest the proliferation of mitogen-stimulated T-cells, which correlated with the induction of Treg cells. Moreover, monocytic cells were essential for the induction of HpHSP60-induced Treg cells via the secretion of IL-10 and TGF-beta after treatment with HpHSP60. Blockage of HpHSP60 with specific monoclonal antibodies significantly reduced the colonization of H. pylori and the expression of Treg cells in vivo. Overall, our results suggest that HpHSP60 could act on macrophages to trigger the expression of IL-10 and TGF-beta, thereby leading to an increase in Treg cells and inhibition of T-cell proliferation.