Browsing by Author "Lin, Wen-Hsin"

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Chromosome 15q21-22-Related Polymorphisms and Haplotypes Are Associated with Susceptibility to Type-2 Diabetic Nonproliferative Retinopathy
(2012-05-01)
Hsieh, Yao-Yuan
;
Huang, Yu-Chuen
;
Chang, Chi-Chen
;
Wang, Yu-Kuo
;
Lin, Wen-Hsin
Objective: Diabetic retinopathy (DR) is a microvascular complication of diabetes with a complex multifactorial pathogenesis. We aimed to investigate whether chromosome 15q21-22-related gene polymorphisms could be used as markers of DR susceptibility in type 2 diabetic (T2D) individuals. Methods: Individuals were divided into three groups: (1) T2D with nonproliferative DR (NPDR; n = 102); (2) T2D with proliferative DR (PDR; n = 72); (3) T2D without DR (n = 573). Six single-nucleotide polymorphisms (SNPs) (rs7174997, rs3751624, rs8025011, rs17818837, rs2922220, and rs2414520) lying within chromosome 15q21-22 region were genotyped by using Illumina HumanHap550-Duo BeadChips. Genotypes/allelic frequencies and haplotypes for these polymorphisms in each group were compared. Results: The MYO5C related SNP (rs3751624)*A related genotype and allele are associated with higher susceptibilities to DR, including PDR and NPDR. The rs3751624*GG/AA + AG percentages in each group are (1) 75.5%/24.5%, (2) 73.6%/26.4%, and (3) 82.5%/17.5%. In contrast, the other five SNPs in each group were not significantly different. One haplotype (G-A-G-G-T-G) appears significantly different between T2D individuals with and without DR. Other haplotype distributions were not significantly different between each group. Conclusion: The MYO5C related SNP (rs3751624)*A related genotype/allele and haplotype (G-A-G-G-T-G) might be associated with susceptibility for retinopathy in T2D individuals. Some chromosome 15q21-22* related genetic variations might contribute to the pathogenesis of DR.
DELETERIOUS EFFECTS OF ARSENIC, BENOMYL AND CARBENDAZIM ON HUMAN ENDOMETRIAL CELL PROLIFERATION IN VITRO
(2010-12-01)
Chang, Chi-Chen
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Hsieh, Yao-Yuan
;
Hsu, Kung-Hao
;
Tsai, Horng-Der
;
Lin, Wen-Hsin
Objective: We aimed to investigate the effects of arsenic (As), benomyl (Ben), and carbendazim (Carb) on endometrial cells. Materials and Methods: Human endometrial cells were obtained during diagnostic curettage. All cultured endometrial cells were divided into four groups: (1) 0 M (controls), (2) 10(-6)M, (3) 10(-5)M, (4) 10(-4)M for As, Ben and Carb. After 24 and 48 hours in culture, endometrial cell proliferations were assessed by diphenyltetrazolium bromide assay. The influences of different concentrations of As, Ben and Garb upon the endometrium were compared. Results: During the first 24 hours, As, Ben and Garb appeared to have insignificant influences upon endometrial growth. After 48 hours in culture, all three agents significantly inhibited endometrial growth. In As groups, cell absorption after 48 hours culture were 100% (group 1), 82.1% (group 2), 43.6% (group 3) and 35.3% (group 4). In Ben groups, cell absorption was 100% (1), 75.9% (2), 66.4% (3) and 49.6% (4). In the Carb groups, cell absorption was 100% (1), 70.4% (2), 73.0% (3) and 76.7% (4). Conclusion: The agents As, Ben and Carb appear to have inhibitory effects upon endometrial cells after 48 hours in culture. [Taiwan J Obstet Gynecol 2010;49(4):449-454]
Intelligent driving assistant systems
(2010-03-17)
Wu, Bing-Fei
;
Chen, Chao-Jung
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Peng, Hsin-Yuan
;
Chen, Ying-Han
;
Lin, Wen-Hsin
The invention discloses an intelligent driving assistant system applied to a handheld device. The invention can detect more than one safety mode including lane departure detection, lost-cargo detection, detecting front-object under driving condition, detecting side-object under driving condition and detecting back-object under driving condition, also the invention can mention alarm according to the detection results from different modules. Finally the invention can store the real-time image according to the detection results from different modules, and then transfer the related information to other places for real-time notice with matching the information from the GPS system and the digitized map.
Mobile Lane Departure Warning Systems
(2009)
Chen, Chao-Jung
;
Wu, Bing-Fei
;
Lin, Wen-Hsin
;
Kao, Chih-Chun
;
Chen, Yi-Han
In this paper, mobile lane departure warning systems (M-LDWS) are addressed. The proposed lane departure warning (LDW) detection algorithm has been successfully implemented on handheld devices with their build-in cameras. The users as long as download LDW program to their own mobile phones and the driving safety service will be enabled. M-LDWS is settled behind the windshield and the driver will be alerted when his car departs from the host lane. M-LDWS detects lane boundaries ahead the host vehicle and estimates the position within the host lane by the captured real-time image. It is qualified to be applied on highways, expressways and urban roadways in Taiwan. It also has been successfully verified in sunny, cloudy and rainy conditions for day and night. M-LDWS will be a novel killer application in consumer devices for driving assistance systems.