Browsing by Author "Lin, Yu-Shiun"

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The effect of centaurein on interferon-gamma expression and Listeria infection in mice
(2007-02-15)
Chang, Shu-Lin
;
Yeh, Hsu-Hua
;
Lin, Yu-Shiun
;
Chiang, Yi-Ming
;
Wu, Tung-Kung
We previously found that centaurein enhanced IFN-gamma transcription in T cells. Here, we demonstrate that centaurein increased the IFN-gamma expression in T and NK cells and the serum IFN-gamma level in mice. Centaurein elevated the transcription of T-bet but not GATA-3, which is consistent with its effect on that of IFN-gamma but not IL-4. Additionally, centaurein effectively protected mice against Listeria infection. Moreover, centaurein per se or in combination with antibiotics could treat Listeria infection. Our mechanistic studies suggest that centaurein augments IFN-gamma expression via a transcriptional up-regulation of T-bet and that centaurein protects against or treats Listeria infection via a modulation of IFN-gamma expression. (c) 2006 Elsevier Inc. All rights reserved.