Browsing by Author "Liu, Ching-Ping"

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Direct Observation of Single Molecule Conformational Change of Tight-Turn Paperclip DNA Triplex in Solution
(2009-10-01)
Liu, Ching-Ping
;
Wey, Ming-Tsai
;
Chang, Chia-Ching
;
Kan, Lou-Sing
;
生物科技學系
DNA triplex modulates gene expression by forming stable conformation in physiological condition. However, it is not feasible to observe this unique molecular structure of large molecule with 54 oligodeoxynucleotides directly by conventional nuclear magnetic approach. In this study, we observed directly single molecular images of paperclip DNA triplexes formation in a buffer solution of pH 6.0 by atomic force microscopy (AFM). Meanwhile, a diffuse "tail" of unwound DNA was observed in pH 8.0 solution. This designable approach in visualizing the overall structures and shapes of oligo-DNAs at the single molecular level, by AFM, is applicable to other biopolymers as well.
In-situ Formation and Assembly of Gold Nanoparticles by Gum Arabic as Efficient Photothermal Agent for Killing Cancer Cells
(2013-10-01)
Liu, Ching-Ping
;
Lin, Fong-Sian
;
Chien, Chih-Te
;
Tseng, Sheng-Yang
;
Luo, Chih-Wei
The B (3)Sigma(-) state of the SO radical
(2006-08-01)
Liu, Ching-Ping
;
Elliott, Nicola L.
;
Western, Colin M.
;
Lee, Yuan-Pern
;
Colin, Reginald
Spectra of the B-3 Sigma(-) - X (3)Sigma(-) transition in SO above the first dissociation limit are recorded using degenerate four wave mixing. These spectra are combined with earlier work involving laser induced fluorescence, absorption spectra and Fourier transform emission spectra, to enable a rotational analysis and deperturbation of vibrational levels of the B state up to v' = 16. Numerous perturbations were noted within the B (3)Sigma(-) state, and the origin of these is discussed. In a number of cases, these perturbations can be attributed to interactions with specific other electronic states of SO, such as A (3)Pi, C (3)Pi, d (1)Pi, and A '' (3)Pi(+). (c) 2006 Elsevier Inc. All rights reserved.