Browsing by Author "Liu, Y. -L."

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COLLAGEN VI PROTECTS AGAINST NEURONAL APOPTOSIS ELICITED BY ULTRAVIOLET IRRADIATION VIA AN AKT/PHOSPHATIDYLINOSITOL 3-KINASE SIGNALING PATHWAY
(2011-06-02)
Cheng, I. H.
;
Lin, Y. -C.
;
Hwang, E.
;
Huang, H. -T.
;
Chang, W. -H.
Collagen VI, one of the extracellular matrix proteins, has been implicated in regulating cell proliferation and reducing apoptosis in several different systems. However, the role of collagen VI in the central nervous system remains unclear. In this manuscript, we demonstrated that upon ultraviolet (UV) irradiation, mouse primary hippocampal neurons specifically up-regulate the expression of Col6a1, Col6a2, and Col6a3 mRNA and secreted collagen VI protein. Augmentation of collagen VI mRNA and protein after UV irradiation may have a neuroprotective role as suggested by the fact that extracellular supplying soluble collagen VI protein, but not other collagen proteins, reduced UV induced DNA damage, mitochondria dysfunction, and neurite shrinkage. We also tried to determine the signaling molecules that mediate the protective effect of collagen VI via Western blot and inhibitor analysis. After collagen VI treatment, UV irradiated neurons increased phosphorylation of Akt and decreased phosphorylation of JNK. Inhibiting Akt/Phosphatidylinositol 3-kinases (PI3K) pathway diminished the protective effect of collagen VI. Our study suggested a potential protective mechanism by which neurons up-regulate collagen VI production under stress conditions to activate Akt/PI3K anti-apoptotic signaling pathway. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
Magnetoelectric effect induced by the delocalised Nb-93m state
(2015-01-02)
Cheng, Y.
;
Guo, Z. -Y.
;
Liu, Y. -L.
;
Young, B. -L.
;
Lee, C. -H.
We herein report on the density- and temperature-dependent decay of the Nb-93m nuclear excited atom and present a simple interpretation of the underlying physics. This anomaly indicates nuclear resonant absorption and delocalisation of the long-lived Mossbauer state in the crystal. A non-linear magnetoelectric response, on low-frequency drive current, appeared in the bulk metal of a high-purity niobium crystal and then disappeared along with the disappearance of delocalised nuclear excitation. Several non-linear resonant peaks, of the order of several hundred Hertz, increased in magnitude with the applied magnetic field, and the central frequencies of these peaks decreased with temperature.