Browsing by Author "Liu, Yu-Hao"

Now showing 1 - 3 of 3

Electroactive Organic Dye Incorporating Dipeptides in the Formation of Self-Assembled Nanofibrous Hydrogels
(2014-10-01)
Liu, Yu-Hao
;
Hsu, Shu-Min
;
Wu, Fang-Yi
;
Cheng, Hsun
;
Yeh, Mei-Yu
In this study, we examined the self-assembly of four dipeptides conjugated with the electroactive dye naphthalenediimide (NDI). The presence of the NDI group at the N-terminus of Phe-Phe and Phe-Gly promoted the formation of one-dimensional (1-D) nanostructures and three-dimensional (3-D) colored hydrogels under both acidic and physiological conditions. The 1-D nanostructures of these gels were stabilized through intermolecular pi pi interactions of the conjugated systems and extended hydrogen bonding of the dipeptide units.
Intramolecular Interactions of a Phenyl/Perfluorophenyl Pair in the Formation of Supramolecular Nanofibers and Hydrogels
(2014-02-10)
Hsu, Shu-Min
;
Lin, Yu-Chun
;
Chang, Jui-Wen
;
Liu, Yu-Hao
;
Lin, Hsin-Chieh
A new system for the incorporation of a phenyl/perfluorophenyl pair in the structure of a peptide hydrogelator was developed. The strategy is based on the idea that the integration of an end-capped perfluorophenyl group and a phenylalanine with a phenyl moiety in the side chain forms an intramolecular phenyl/perfluorophenyl pair, which can be used to promote the formation of the supramolecular nanofibers and hydrogels. This work illustrates the importance of structure-hydrogelation relationship and provides new insights into the design of self-assembly nanobiomaterials.
Nanofibrous hydrogels self-assembled from naphthalene diimide (NDI)/amino acid conjugates
(2015-01-01)
Hsu, Ling-Huang
;
Hsu, Shu-Min
;
Wu, Fang-Yi
;
Liu, Yu-Hao
;
Nelli, Srinivasa Rao
The combination of a naphthalene diimide (NDI) group and a single amino-acid of serine (Ser) or lysine (Lys) can be used to promote the formation of a supramolecular hydrogel, which indicates the aromatic amino acid is not necessary to be used in the structural design of NDI-capped small molecule hydrogelators. An equimolar ratio of NDI-Ser and NDI-Lys can form a stable hydrogel under neutral conditions and its gel-to-sol transition temperature is higher than 37 degrees C. This work, as the first example of NDI-containing hydrogelators without aromatic rings in the side chains of amino acids, illustrates a new approach to design NDI-capped supramolecular hydrogels.