Browsing by Author "Lu, KC"

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Chemoselective deprotection of acid labile primary hydroxyl protecting groups under CBr4-photoirradiation conditions
(2004-12-06)
Chen, MY
;
Patkar, LN
;
Lu, KC
;
Lee, ASY
;
Lin, CC
The CBr4-photoirradiation in methanol generates a controlled source of HBr, which can chemoselectively deprotect commonly used hydroxyl-protecting groups in saccharides and nucleosides, such as tert-butyldimethylsilyl, isopropylidene, benzylidene and triphenyl ethers in the presence of other acid-labile functional groups. (C) 2004 Elsevier Ltd. All rights reserved.
Simple and efficient per-O-acetylation of carbohydrates by lithium perchlorate catalyst
(2004-09-27)
Lu, KC
;
Hsieh, SY
;
Patkar, LN
;
Chen, CT
;
Lin, CC
Lithium perchlorate is demonstrated to be a highly efficient and convenient catalyst for the per-O-acetylation of various saccharides with excellent yields. (C) 2004 Elsevier Ltd. All rights reserved.
Synthesis of alpha-galactosyl ceramide and the related glycolipids for evaluation of their activities on mouse splenocytes
(2005-02-14)
Fan, GT
;
Pan, YS
;
Lu, KC
;
Cheng, YP
;
Lin, WC
Phytosphingosine and its short-chain analog were efficiently synthesized with 19% overall yield in 10 steps, respectively, starting from an inexpensive D-lyxose. Galactosyl donors of sulfide and phosphite types bearing benzoyl protecting groups of 4- and 6OH underwent glycosylation in excellent alpha-anomeric selectivity. A variety of alpha-galactosyl, fucosyl and glucosyl ceramides and serine-type lipids were prepared, and their activities involved in the proliferation of mouse splenocytes and the expression of cytokines were elucidated. Besides alpha-galactosyl ceramides, a galactosyl serine-type lipid also exhibited substantial effect on the expression of cytokines IFN-gamma and IL-4. (C) 2004 Elsevier Ltd. All rights reserved.