<link rel="stylesheet" href="styles.cf390c6bfbe7555f.css">

Browsing by Author "Lu, Ming-Kuei"

Now showing 1 - 4 of 4
  • Thumbnail Image
    Item type:Item,
    Anatomic Differences between Parkinson\'s Disease and Essential Tremor Using ICA-based Brain Morphometry
    (2013)
    Duann, Jeng-Ren
    ;
    Lin, Ching-Hung
    ;
    Chen, Chun-Min
    ;
    Lu, Ming-Kuei
    ;
    Tsai, Chon-Haw
    This study used independent component analysis (ICA) to decompose the surrogate image data by concatenating in space multiple subjects\' anatomical images after spatial normalization and smoothing to make all images in the same space. The multiple-subject anatomical image data included three different subject/patient populations, namely the Parkinson\'s disease (PD) and essential tremor (ET) as well as age-matched normal control (NC) subjects. In so doing, we were to extract the independent components showing significant group differences caused by the morphometric changes due to the neurological diseases. Such an independent component-based morphometry (ICBM) applied to both the grouped gray-matter and white-matter image data could be used to successfully reveal the brain areas within the gray and white matters showing significant group differences. In gray matter, we found a majority of basal ganglia brain areas associated with NC > PD, which well represented the causes of PD reported in the literature. In addition, the ICBM also found the brain areas of right superior temporal gyrus, right angular gyrus (BA 39), right inferior temporal gyrus, and left middle temporal gyrus (BA 37) associated with NC > ET. On the other hand, a more complicated patterns were found in the white matter associated with PD > ET and ET > PD conditions.
  • Thumbnail Image
    Item type:Item,
  • Thumbnail Image
    Item type:Item,
    The role of the sub-thalamic nucleus in the preparation of volitional movement termination in Parkinson's disease
    (2012-01-01)
    Hsu, Yi-Ting
    ;
    Lai, Hsin-Yi
    ;
    Chang, Yao-Chuan
    ;
    Chiou, Shang-Ming
    ;
    Lu, Ming-Kuei
    The sub-thalamic nucleus (STN) is relevant to the preparation of movement ignition but its role in movement termination is uncertain. Fourteen patients with Parkinson's disease (PD) received local field potentials (LFPs) recording at the left STN on the fourth day after deep brain stimulation surgery. They performed phasic and tonic movements of the right wrist extensor. Movement onset (Mon) and movement offset (Moff) of the electromyographic activities were used as triggers to determine an eight-second LFPs epoch for time-frequency analysis. Movement-related power changes were assessed by repeated measures analysis of variance with within-subject factors of Event (Mon and Moff), Period (ten time periods for phasic movement and six time periods for tonic movement), and Frequency (alpha, low-beta, and high-beta). There was significant triple interaction in both the phasic and tonic movements. By post-hoc analysis, high-beta event-related desynchronization (ERD) appeared earlier (3 s prior to Mon) than those of low-beta and alpha for the Mon phasic movement. There was no alpha ERD for the Mon tonic movement. Alpha, low-beta, and high-beta ERD all appeared about 1 s prior to the Moff tonic movement. The current findings suggest that STN participates in the preparation of volitional movement termination but via a different mechanism from that in movement initiation. Unlike asynchronous ERD frequency bands present in movement initiation, a simultaneous ERD across wide frequency bands in STN may play a pivotal role in terminating volitional movement. (C) 2011 Elsevier Inc. All rights reserved.
  • Thumbnail Image
    Item type:Item,
    VBM reveals brain volume differences between Parkinson's disease and essential tremor patients
    (2013-06-14)
    Lin, Ching-Hung
    ;
    Chen, Chun-Ming
    ;
    Lu, Ming-Kuei
    ;
    Tsai, Chon-Haw
    ;
    Chiou, Jin-Chern
    Symptoms of essential tremor (ET) are similar to those of Parkinsons disease (PD) during their initial stages. Presently, there are few stable biomarkers available on a neuroanatomical level for distinguishing between these two diseases. However, few investigations have directly compared the changes in brain volume and assessed the compensatory effects of a change in the parts of the brain associated with PD and with ET. To determine the compensatory and/or degenerative anatomical changes in the brains of PD and ET patients, the present study tested, via two voxel-based morphometry (VBM) approaches (Basic vs. DARTEL VBM processing), the anatomical brain images of 10 PD and 10 ET patients, as well as of 13 age-matched normal controls, obtained through a 3T magnetic resonance scanner. These findings indicate that PD and ET caused specific patterns of brain volume alterations in the brains examined. In addition, our observations also revealed compensatory effects, or self-reorganization, occurring in the thalamus and the middle temporal gyrus in the PD and ET patients, due perhaps in part to the enhanced thalamocortical sensorimotor interaction and the head-eye position readjustment, respectively, in these PD and ET patients. Such a distinction may lend itself to use as a biomarker for differentiating between these two diseases.