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Browsing by Author "Nicholls, Stephen J."

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    The use of polymer-based nanoparticles and nanostructured materials in treatment and diagnosis of cardiovascular diseases: Recent advances and emerging designs
    (2016-06)
    Wang, Yen-Jen
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    Larsson, Mikael
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    Huang, Wei-Ting
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    Chiou, Shih-Hwa
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    Nicholls, Stephen J.
    This review summarizes important advances in polymer-based nanotechnologies for the treatment and diagnosis of cardiovascular diseases, focusing on nanoparticles and nanostructured materials/devices. The current state of the art and design parameters are discussed with the aim of providing a source of information that can aid in the development of new treatments by bridging between materials development, preclinical, and clinical trials. This is highly relevant as cardiovascular diseases remain a leading cause of death worldwide and as current treatments burden the healthcare systems with great costs. Different strategies, from targeting theranostic nanocarriers, to dual-drug depot systems, injectable cell scaffolds, and LDL acceptors are treated. The review ends with a concluding outlook on the ossibilities and challenges presented to polymer-based nanotechnologies in cardiovascular disease therapy. (c) 2016 Elsevier Ltd. All rights reserved.