Browsing by Author "Peng, Bo-Kai"

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Temperature-Controlled Thiation of alpha-Cyano-beta-Alkynyl Carbonyl Derivatives for De Novo Synthesis of 2-Aminothiophenes and Thieno[2,3-c]isothiazoles
(2018-12-07)
Kao, Tzu-Ting
;
Peng, Bo-Kai
;
Liang, Min-Chieh
;
Lee, Chia-Jui
;
Chen, I-Chia
Making use of temperature-controlled thiation as a key operation, a simple route to 2-aminothiophenes or thieno[2,3-c]isothiazoles has been newly developed wherein the 2-aminothiophene nucleus was formed through an initial formation of thioamide followed by a 5-exo-dig addition to the tethered alkyne; however, under harsher thermal conditions, excess sulfur-transferring reagents enabled further oxidative thiation to generate the corresponding thieno[2,3-c]isothiazoles.