<link rel="stylesheet" href="styles.cf390c6bfbe7555f.css">

Browsing by Author "Peng, Wan-Ling"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item type:Item,
    Palladium-catalyzed alpha-arylation of indolin-3-ones
    (2020-04-30)
    Chang, Yu-Hsuan
    ;
    Peng, Wan-Ling
    ;
    Chen, I-Chia
    ;
    Hsu, Hsin-Yun
    ;
    Wu, Yen-Ku
    A method for the catalytic alpha-arylation of indolin-3-ones was developed. The catalytic system comprising Pd(dba)(2) and PAd(3) was found to be optimal for the transformation. The protocol features broad functional group compatibility in that a range of arylated indoxyl derivatives bearing a fully substituted carbon center was synthesized with high efficiency. A preliminary bioassay study revealed that the selected indole-substituted indolin-3-ones exhibit favorable cytotoxic activities against HCT-116 cancer cell line.