Browsing by Author "Premkumar, N."

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Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins
(2008-10-01)
Kalkhambkar, Rajesh G.
;
Kulkarni, Geeta M.
;
Kamanavalli, Chandrappa M.
;
Premkumar, N.
;
Asdaq, S. M. B.
A series of new fluorinated coumarins and 1-aza coumarins have been synthesized and the presence of fluorine in these molecules and its effect on their anti-microbial, anti-inflammatory and analgesic activities are discussed. The results of bioassay showed that these newly synthesized compounds containing fluorine exhibit moderate analgesic and excellent anti-inflammatory and potential anti-bacterial and anti-fungal activities, compared to the other halogenated compounds. All the newly synthesized compounds were characterized by elemental analysis, IR, (1)H NMR, (13)C NMR, (19)F NMR, EI-MS, and FAB-MS. The ORTEP diagram of one of the compounds is reported herein. (C) 2007 Elsevier Masson SAS. All rights reserved.