Browsing by Author "Su, Ying-Wen"

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cIAP-2 Expression Increases in Elderly Patients with Squamous Cell Carcinoma of the Head and Neck
(2017-03-01)
Chen, Chi-Long
;
Chiang, Chun-Yi
;
Liao, Kuang-Wen
;
Ho, Shu-Yi
;
Chang, Yi-Fang
Background: Evidence indicates apoptosis deregulation is associated with aging. We correlated expression of cIAP-2, a member of the inhibitor of apoptosis protein family, with survival and age in patients with resected squamous cell carcinoma of head and neck (SCCHN). Methods: Immunohistochemical (IHC) staining for cIAP-2 and other markers were performed using tissue microarrays from 103 resected SCCHN patients. Expression was grouped according to IHC scores (0 -3) and statistical association with clinicalepathological factors was determined. Results: High expression of cIAP-2 was found to be increased in patients aged 60 or greater. High expression of cIAP-2 and an age >= 60 were significantly associated with worse survival in univariate analysis, but only an age >= 60, and not cIAP-2 expression, was prognostic in multivariate analysis. Conclusion: High expression of cIAP-2 was found more frequently in elderly SCCHN patients but was not independently associated with survival after adjusting other clinicalepathologic factors. Copyright (C) 2017, Taiwan Society of Geriatric Emergency & Critical Care Medicine. Published by Elsevier Taiwan LLC.