Browsing by Author "Syue, Ling-Shan"

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New drugs for the treatment of complicated intra-abdominal infections in the era of increasing antimicrobial resistance
(2016-04)
Syue, Ling-Shan
;
Chen, Yen-Hsu
;
Ko, Wen-Chien
;
Hsueh, Po-Ren
;
生醫工程研究所
The continuing increase in multidrug-resistant organisms (MDROs) worldwide has created new challenges in treating complicated intra-abdominal infections (cIAIs). A number of novel antimicrobial agents have been developed against resistant pathogens. To target extended-spectrum beta-lactamase (ESBL)-producing pathogens, novel beta-lactam antibiotics, such as ceftolozane/tazobactam, ceftazidime/avibactam, aztreonam/avibactam, imipenem/relebactam and S-649266, are antimicrobial alternatives for cIAIs. Two new drugs, eravacycline and plazomicin, have activity against Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae, carbapenem-resistant Acinetobacter baumannii and ESBL-producers. New lipoglycopeptides and oxazolidinones provide feasible options against resistant Gram-positive pathogens. These novel antimicrobials may play a role in improving the clinical outcomes of cIAIs caused by MDROs. (C) 2016 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.