Browsing by Author "Tai, Hung-Che"

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Nucleophilic Conjugate 1,5-Addition of Gilman Reagents to (E)-Hex-2-en-4-ynedioates: An Access to ()-Substituted Muconates
(2015-08-01)
Tai, Hung-Che
;
Chavan, Arjun S.
;
Chuang, Shih-Ching
;
應用化學系
;
Department of Applied Chemistry
An unusual nucleophilic conjugate addition of organocuprates to enynedioates resulted in chemo- and regioselective formation of ()-addition products, rather than ()-addition products, in moderate to good yields. This addition pattern is different from that with organophosphanes or alkyl amines, and presents a short and efficient method for the preparation of various ()-alkyl- or -aryl-substituted muconates compared with other synthetic approaches.