Browsing by Author "Tung, Tsan-Hua"

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In situ synthesis of hybrid nanocomposite with highly order arranged amorphous metallic copper nanoparticle in poly(2-hydroxyethyl methacrylate) and its potential for blood-contact uses
(2008-11-01)
Liu, Yen-Yu
;
Liu, Dean-Mo
;
Chen, San-Yuan
;
Tung, Tsan-Hua
;
Liu, Tse-Ying
A hybrid consisting of a highly ordered nanostructure of metallic Cu(0) nanoparticles embedded in a poly(2-hydroxyethyl methacrylate) (pHEMA) matrix was successfully synthesized by in situ photopolymerization, followed by in situ chemical reduction. The evolution of an ordered nanostructure of Cu(0) showing a nearly amorphous nature is discussed, and it is proposed that it is due to a coupling interaction between the Cu precursor and the unpaired O of the COOR group, associated with water molecules, among pHEMA molecules. The hybrids showed a negative surface charge and considerable improvement in blood compatibility compared to neat pHEMA and the widely used biomaterial polysulfonate. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Nano-hybrid carboxymethyl-hexanoyl chitosan modified with (3-aminopropyl)triethoxysilane for camptothecin delivery
(2012-06-20)
Hsiao, Meng-Hsuan
;
Tung, Tsan-Hua
;
Hsiao, Chi-Sheng
;
Liu, Dean-Mo
;
材料科學與工程學系
Silane-modified amphiphilic chitosan was synthesized by anchoring a silane coupling agent, (3-aminopropyl)triethoxysilane, to a novel amphiphilic carboxymethyl-hexanoyl chitosan (CHC). The chemical structure of this new organic-inorganic hybrid molecule was characterized by FTIR and C-13-, Si-29-nuclear magnetic resonance, while the structural evolution was examined using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and dynamic light scattering (DLS). Experimental results indicated a self-assembly behaviour of molecules into nanopartides with a stable polygonal geometry, consisting of ordered silane layers of 6 nm in thickness. The self-assembly property was found to be influenced by chemical composition and concentration of silane incorporated, while the size can be varied by the amount of anchored silane. It was also demonstrated that such vesicle exhibited excellent cytocompatibility and cellular internalization capability in ARPE-19 cell line, and presented well-controlled encapsulation and release profiles for (S)-(+)-camptothecin. These unique properties render it as a potential drug delivery nanosystem. (C) 2012 Elsevier Ltd. All rights reserved.
Remotely nano-rupturable yolk/shell capsules for magnetically-triggered drug release
(2011)
Hu, Shang-Hsiu
;
Chen, You-Yin
;
Liu, Ta-Chung
;
Tung, Tsan-Hua
;
Liu, Dean-Mo
Yolk/shell capsules containing a volume/hydrophobicity transformable core and an ultra-thin silica shell have been prepared. When an external magnetic field induced the temperature, the cores exhibit a significant triggering size shrinkage and the diameter decreases more than 10 times, causing solid shells destruction and physical collapse, leading to drug burst release.
Structural Evolution and Copper-Ion Release Behavior of Cu-pHEMA Hybrids Synthesized In Situ
(2009-11-01)
Liu, Yen-Yu
;
Tung, Tsan-Hua
;
Liu, Kun-Ho
;
Chen, San-Yuan
;
Liu, Dean-Mo
A novel Cu-pHEMA hybrid was successfully prepared by in situ photopolymerization of 2-hydroxyethyl methacrylate (HEMA) monomer in the presence of COP copper ions, following an in situ chemical reduction. Experimental observations indicate that intermolecular interactions such as the coupling force and hydrogen bonding between the Cu and the hydroxyl groups further stabilize the hybrid structure to a considerable extent. Localization of the metallic copper particles within the pHEMA network structure as a result of those intermolecular interactions gives rise to the formation of discretely distributed nanocrystallites with particle sizes ranging from 5 to 25 nm in diameter, A crystallographic change of the Cu nanophase from an amorphous-like to a crystalline structure is observed as the H(2)O:HEMA molar ratio increases, upon synthesis, accompanied with an increase in the particle size, A relatively slow and sustained release of the Cu (in the form of cupric ions) from the hybrids was measured for a time period of about 10 days, which also illustrates a Cu(II)-induced proliferation of the endothelial cells over a relatively small range of release rate of the Cu from the hybrids. Such a new type of Cu-loaded hybrid hydrogel is expected to be compatible and may be considered as a candidate biomaterial for biomedical/therapeutic uses.